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. 1976 May;9(5):800–803. doi: 10.1128/aac.9.5.800

Cefatrizine (SK&F 60771), a New Oral Cephalosporin: Serum Levels and Urinary Recovery in Humans After Oral or Intramuscular Administration – Comparative Study with Cephalexin and Cefazolin

Paul Actor *, Donald H Pitkin †, George Lucyszyn †, Jerry A Weisbach †, José L Bran †
PMCID: PMC429624  PMID: 949177

Abstract

Cefatrizine (SK&F 60771), a new broad-spectrum cephalosporin, was administered in a 0.5-g dose either orally or intramuscularly to volunteers in a crossover study. After oral administration, the average peak serum levels were 5.6 and 22.1 μg/ml for cefatrizine and cephalexin, respectively. The serum half-life of cefatrizine appeared to be more extended than that of cephalexin. Urinary recovery of cefatrizine (35%) was approximately half that of cephalexin (68%) after oral administration. After intramuscular injection of 0.5 g, the average peak serum level of cefatrizine (12.0 μg/ml) was approximately one-fourth that of cefazolin (44.0 μg/ml). The serum half-life after intramuscular injection was 86 min for cefatrizine and 118 min for cefazolin. Urinary recovery was 45% of the intramuscularly administered dose, as compared with cefazolin, which was 74%.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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