Unilateral Angle-Closure Glaucoma with Ciliochoroidal Effusion after the Consumption of Cannabis: A Case Report

Abstract

A 35-year-old male patient, diagnosed with acute angle-closure glaucoma, did not improve despite intensive treatment with antiglaucoma medications. Ultrasound biomicroscopy revealed a ciliochoroidal effusion. Due to his past history of drug abuse, a urine test was analyzed and found to be positive for cannabis. After topical cycloplegia and oral steroid therapy, his symptoms improved substantially. The present case highlights the role of ultrasound biomicroscopy in evaluating patients with acute angle-closure glaucoma and the role of cannabis abuse in the development of ciliochoroidal effusion.

Case Presentation

A 35-year-old male patient was admitted to our emergency room due to severe right eye pain for 2 days prior to his arrival. There was no significant ocular or medical history. He was not on any prescribed systemic or ocular medication. He reported good visual acuity and no refractive correction.

On initial examination, his best-corrected visual acuity was 20/80 OD and 20/20 OS. Intraocular pressure (IOP) was 25 mm Hg OD and 12 mm Hg OS. A slit-lamp examination of the right eye revealed a hyperemic conjunctiva, a shallow central and peripheral anterior chamber depth, and his pupil was miotic. His left eye examination was unremarkable. A gonioscopy on his OD revealed a closed angle, not reacting to indentation. The OS anterior chamber angle was wide open. He developed an acute myopic shift of −2.5 diopters OD and −0.5 OS. The axial length was 23.67 mm OD and 23.84 mm OS. Fundus examination, including the optic nerve head, was normal in both eyes. He was treated with topical applications of pilocarpine 2% every 15 min for 2 h, timolol 0.5% every 12 h, brimonidine 0.2% every 12 h, and acetazolamide 1% every 12 h. After 1 h, his IOP returned to normal and the symptoms decreased. After 2 h following this improvement, he reported a recurrence of the symptoms, and an elevation of his IOP (26 mm Hg OD) was noticed.

An ultrasound biomicroscopy (UBM) was performed to evaluate the angle and ciliary body region (fig. 1, fig. 2). An UBM of his OD revealed a closed angle, choroidal effusion, anteriorly rotated ciliary processes, and obscure ciliary sulci (fig. 1, fig. 2). The performed UBM of his OS revealed an open angle and no signs of choroidal effusion. Treatment with topical cycloplegia and oral steroids was started, and his symptoms improved substantially.

Fig. 1.

A right eye UBM photograph demonstrating a closed angle, choroidal effusion, anteriorly rotated ciliary processes, and obscure ciliary sulci.

Fig. 2.

A right eye UBM photograph demonstrating ciliochoroidal effusion. The choroidal thickness measured 1.14 mm with septate formation.

His visual fields were normal in both eyes, and the retinal fluorescein angiography was normal. Repeated enquiries about medication or drug use revealed marijuana abuse. A urine test for toxic substances was found to be positive for cannabis.

Discussion

Angle closure is often erroneously considered synonymous with a pupillary block, the most common mechanism leading to acute or chronic iridocorneal apposition. Ritch et al. [1] and Tello et al. [2] have described a 4-point classification of these mechanisms and, in addition to a pupillary block occurring at the level of the iris, have included mechanisms originating in the ciliary body, lens, or posterior segment.

UBM has led to the description of clinical cases indistinguishable from malignant glaucoma. These cases, in which the accumulation of supraciliary fluid leads to the detachment and anterior rotation of the ciliary body and consequent angle closure, may be part of diffuse choroidal detachments observable with B-scan ultrasounds, or a subtle finding observable only with UBM. Medical therapy only may be indicated for these patients, highlighting the need for a careful diagnosis.

Several classes of drugs are known to precipitate angle-closure glaucoma including adrenergic agonists, cholinergics, anticholinergics, sulpha-based drugs, selective serotonin reuptake inhibitors, tricyclic and tetracyclic antidepressants, anticoagulants and histamine H₁ and H₂ receptor antagonists. Tripathi et al. [3] proposed that the mechanism of drug-induced angle closure is by narrowing the angle of the anterior chamber, by pupillary dilatation, by forward movement of the iris/lens diaphragm (pupillary block glaucoma), and by swelling of the ciliary body/epithelium, lens, or vitreous body.

THC (tetrahydrocannabinol) is a cannabinoid contained in marijuana. The pupillary action of THC is controversial [4, 5, 6].

The controversy may be due to differences in the conditions under which the experiments were performed as well as to differences of drug purity.

The angle-closure glaucoma in our patient is best explained by a pushing mechanism in which the choroidal effusion leads to detachment and anterior rotation of the ciliary body and consequent angle closure.

The acute myopia can probably be explained by the forward displacement of the lens caused by supraciliary effusion, although ciliary body swelling and lens thickening could also play a role [7].

Although the idiosyncratic drug reactions and systemic inflammatory conditions have been associated with bilateral anterior chamber shallowing and angle closure [8, 9, 10, 11], our patient developed unilateral ciliochoroidal effusion. This can be attributed to the fact that the patient achieved medical treatment immediately after the unilateral symptoms have developed, and therefore, no symptoms in the contralateral eye developed.

There has been only 1 report of marijuana in combination with ‘ecstasy’ which induced acute bilateral angle closure. However, the mechanism of angle closure was not directly attributed to marijuana alone nor was there any documentation of ciliochoroidal effusion [12].

Kumar et al. [13] reported a case of ‘ecstasy’-induced bilateral angle closure and transient myopia with ciliochoroidal effusion.

Marijuana affects serotonin pathways by upregulating and enhancing serotonin receptors [14, 15]. Serotonergic innervation in the eye and the presence of serotonin and serotonin receptors in the aqueous humour and ciliary body have been reported [16, 17].

Although the precise mechanism is unknown, the supraciliary effusion in our patient could imply a serotonergic effect of marijuana.

Although it is undisputed that smoking of the marijuana plant material causes a fall in IOP in 60–65% of users, smoking reduces the IOP for only 3–4 h, after which it returns to baseline. Continued use at a rate needed to control glaucomatous IOP would lead to a substantial systemic toxic effect revealed to as pathological changes [18, 19].

Conclusion

In conclusion, marijuana abuse should be kept in mind as a differential diagnosis for drug-induced acute onset of angle-closure glaucoma and transient myopia with ciliochoroidal effusion.

Disclosure Statement

The authors declare no conflict of interest.