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. 1976 May;9(5):852–855. doi: 10.1128/aac.9.5.852

Activity of Cefamandole and Other Cephalosporins Against Aerobic and Anaerobic Bacteria

E Chaim Ernst 1,1, Stephen Berger 1,2, Michael Barza 1, Nilda V Jacobus 1, Francis P Tally 1
PMCID: PMC429632  PMID: 949182

Abstract

The activity of cefamandole was comparable to that of cephalothin, cefazolin, and cephaloridine against Staphylococcus aureus, Streptococcus pyogenes, and Diplococcus pneumoniae. In contrast, cefamandole was considerably more active than cephalothin, cefazolin, or cephaloridine against gram-negative facultative bacilli, including Haemophilus influenzae, the most striking disparities being noted with indole-positive Proteus and Enterobacter. Bacteroides fragilis was more susceptible to cefoxitin than to cefamandole or cefazolin (median minimal inhibitory concentration, approximately 8, 32, and 32 μg/ml, respectively); cephalothin exhibited still less activity against this species. The majority of other anaerobes were inhibited by relatively low concentrations of all four cephalosporins. The results indicate a potentially valuable role for cefamandole against facultative gram-negative bacilli, including H. influenzae, but no exceptional activity against anaerobes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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