Abstract
A new 3-N-aminoglycoside acetyltransferase is described, which possesses a wider substrate range than any such enzyme so far discovered in clinical isolates of antibiotic-resistant bacteria.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brzezinska M., Benveniste R., Davies J., Daniels P. J., Weinstein J. Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymatic N-acetylation of the deoxystreptamine moiety. Biochemistry. 1972 Feb 29;11(5):761–765. doi: 10.1021/bi00755a013. [DOI] [PubMed] [Google Scholar]
- Cooper D. J., Weinstein J., Waitz J. A. Gentamicin antibiotics. 4. Some condensation products of gentamicin C2 with aromatic and aliphatic aldehydes. J Med Chem. 1971 Nov;14(11):1118–1120. doi: 10.1021/jm00293a026. [DOI] [PubMed] [Google Scholar]
- Haas M., Biddlecome S., Davies J., Luce C. E., Daniels P. J. Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate. Antimicrob Agents Chemother. 1976 Jun;9(6):945–950. doi: 10.1128/aac.9.6.945. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kojima M., Ezaki N., Amano S., Inouye S., Nida T. Bioconversion of ribostamycin (SF-733). II. Isolation and structure of 3-N-acetylribostamycin, a microbiologically inactive product of ribostamycin produced by Streptomyces ribosidificus. J Antibiot (Tokyo) 1975 Jan;28(1):42–47. doi: 10.7164/antibiotics.28.42. [DOI] [PubMed] [Google Scholar]
- Le Goffic F., Martel A., Witchitz J. 3-N enzymatic acetylation of gentamicin, tobramycin, and kanamycin by Escherichia coli carrying an R factor. Antimicrob Agents Chemother. 1974 Dec;6(6):680–684. doi: 10.1128/aac.6.6.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Umezawa H., Yagisawa M., Matsuhashi Y., Naganawa H., Yamamoto H. Letter: Gentamicin acetyltransferase in Escherichia coli carrying R factor. J Antibiot (Tokyo) 1973 Oct;26(10):612–614. doi: 10.7164/antibiotics.26.612. [DOI] [PubMed] [Google Scholar]
- Williams J. W., Northrop D. B. Purification and properties of gentamicin acetyltransferase I. Biochemistry. 1976 Jan 13;15(1):125–131. doi: 10.1021/bi00646a019. [DOI] [PubMed] [Google Scholar]