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. 1976 Jul;10(1):14–19. doi: 10.1128/aac.10.1.14

Antiviral and Interferon-Inducing Activity of a New Glutarimide Antibiotic, 9-Methylstreptimidone

Noriyuki Saito 1, Fujio Suzuki 1, Kenji Sasaki 1, Nakao Ishida 1
PMCID: PMC429681  PMID: 984746

Abstract

The antiviral effect of 9-methylstreptimidone (9-MS) was examined in mice infected with mouse-adapted influenza A2 (H2N2) virus. Both a single and continuous prophylactic administration of 9-MS protected mice from virus infection, and comparison between the minimal effective and the 50% lethal dose gave a therapeutic index of 60. When the treatment was started after infection, however, no antiviral effect was demonstrated. After a single intraperitoneal administration of 9-MS, a highly potent virus-inhibitory factor was detected in the lungs (10 h later) and the sera (16 h later) of uninfected mice, which was assumed to be an interferon on the basis of the biological characteristics. These results suggest that the protective activity of the antibiotic is due to interferon induction in mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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