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. 1976 Jul;10(1):25–27. doi: 10.1128/aac.10.1.25

Pharmacokinetic Parameters of Sisomicin

Burt R Meyers 1, Shalom Z Hirschman 1, Stanley Yancovitz 1, Bruce Ribner 1
PMCID: PMC429683  PMID: 984754

Abstract

Sisomicin in doses of 1 mg/kg was administered intramuscularly to 10 healthy volunteers, and 1 week later the same volunteers received sisomicin at the same dose intravenously. A peak serum concentration of sisomicin of 3.08 μg/ml was obtained 1 h after intramuscular injection, and a peak serum concentration of 7.12 μg/ml was achieved 30 min after a 30-min intravenous infusion. The sisomicin elimination data were analyzed according to a two-compartment model. Pharmacokinetic parameters derived from the intramuscular and intravenous studies were quite similar.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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