Abstract
Subtherapeutic levels of oxytetracycline plus neomycin in animal feeds did not bring about increases in the quantity, prevalence, or shedding of Salmonella typhimurium in swine, calves, or chickens. In fact, the medication generally reduced the proportion of animals carrying S. typhimurium. The medicated groups were fed rations containing oxytetracycline plus neomycin commencing 5 days prior to oral inoculation with S. typhimurium and continuing through a 28-day postinoculation period. Colonization of S. typhimurium occurred in all three animal species, as evidenced by clinical signs of infection and/or colony counts in feces. Only from swine and on only one occasion was a single resistant colony isolated. It is concluded that no evidence has been obtained which would implicate the continuous low-level feeding of oxytetracycline and neomycin for a 4-week period to a potential increased incidence of disease in animals or as a hazard to humans.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Evangelisti D. G., English A. R., Girard A. E., Lynch J. E., Solomons I. A. Influence of subtherapeutic levels of oxytetracycline on Salmonella typhimurium in swine, alves, and chickens. Antimicrob Agents Chemother. 1975 Dec;8(6):664–672. doi: 10.1128/aac.8.6.664. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith H. W. The incidence of infective drug resistance in strains of Escherichia coli isolated from diseased human beings and domestic animals. J Hyg (Lond) 1966 Dec;64(4):465–474. doi: 10.1017/s0022172400040778. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith H. W. The transfer of antibiotic resistance between strains of enterobacteria in chicken, calves and pigs. J Med Microbiol. 1970 Feb;3(1):165–180. doi: 10.1099/00222615-3-1-165. [DOI] [PubMed] [Google Scholar]