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. 1976 Jul;10(1):119–122. doi: 10.1128/aac.10.1.119

Antiviral Action and Cellular Toxicity of Four Thymidine Analogues: 5-Ethyl-, 5-Vinyl-, 5-Propyl-, and 5-Allyl-2′-Deoxyuridine

Yung-Chi Cheng 1, Barbara A Domin 1, Ram A Sharma 1, Miroslav Bobek 1
PMCID: PMC429699  PMID: 185944

Abstract

5-Ethyl-, 5-vinyl-, 5-propyl-, and 5-allyl-2′-deoxyuridine (dUrd) had antiviral activity against herpes simplex type 1 and type 2 grown in HeLa TK− cells, in the order 5-vinyl-dUrd, 5-ethyl-dUrd, 5-propyl-dUrd, 5-allyl-dUrd, but they were inactive against a TK− mutant of herpes simplex type 1. The antiviral activity of these compounds could be partially reversed by thymidine. Except for 5-vinyl-dUrd, they were not toxic to WI-38 and HeLa TK− cells at a concentration of 25 μM. All four analogues inhibited the growth of herpes simplex type 1-transformed HeLa TK− cells at a concentration of 1 μM.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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