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. 1976 Aug;10(2):200–204. doi: 10.1128/aac.10.2.200

Effect of Long-Term Therapies with Penicillin and Sulfadiazine on Streptococcus mutans and Lactobacilli in Dental Plaque

H G Weld a,1, H J Sandham a
PMCID: PMC429720  PMID: 984761

Abstract

Plaque samples were obtained from 13 children receiving long-term therapy with benzathine penicillin for the prevention of rheumatic fever recurrences, 31 children receiving oral sulfadiazine for the same purpose, and 29 untreated siblings. The therapies were found to have no effect upon the proportions of Streptococcus mutans or lactobacilli in dental plaque, upon the percentage of children harboring the organisms, nor upon the susceptibility of the organisms to penicillin and sulfadiazine. Of the S. mutans strains tested, 97% had a minimal inhibitory concentration of penicillin G of less than 48 ng/ml and, of the lactobacillus strains tested, 96.8% had a minimal inhibitory concentration of less than 1,600 ng/ml. All strains of both organisms were profoundly resistant to sulfadiazine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker C. N., Thornsberry C. Antimicrobial susceptibility of Streptococcus mutans isolated from patients with endocarditis. Antimicrob Agents Chemother. 1974 Mar;5(3):268–271. doi: 10.1128/aac.5.3.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carlsson J. A numerical taxonomic study of human oral streptococci. Odontol Revy. 1968;19(2):137–160. [PubMed] [Google Scholar]
  3. Ericsson H. M., Sherris J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217(Suppl):1+–1+. [PubMed] [Google Scholar]
  4. FITZGERALD R. J., ZANDER H. A., JORDAN H. V. The effects of a penicillin dentifrice on oral lactobacilli. J Am Dent Assoc. 1950 Jul;41(1):62–65. doi: 10.14219/jada.archive.1950.0140. [DOI] [PubMed] [Google Scholar]
  5. Fitzgerald R. J. Inhibition of experimental dental caries by antibiotics. Antimicrob Agents Chemother. 1972 Apr;1(4):296–302. doi: 10.1128/aac.1.4.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GREEN G. E., DODD M. C., INVERSO H. S. Comparative microflora of developing dental plaques in caries-immune and susceptible individuals. J Dent Res. 1957 Jun;36(3):331–337. doi: 10.1177/00220345570360030201. [DOI] [PubMed] [Google Scholar]
  7. Gibbons R. J., van Houte J. On the formation of dental plaques. J Periodontol. 1973 Jun;44(6):347–360. doi: 10.1902/jop.1973.44.6.347. [DOI] [PubMed] [Google Scholar]
  8. Gold O. G., Jordan H. V., Van Houte J. A selective medium for Streptococcus mutans. Arch Oral Biol. 1973 Nov;18(11):1357–1364. doi: 10.1016/0003-9969(73)90109-x. [DOI] [PubMed] [Google Scholar]
  9. HANDELMAN S. L., HAWES R. R. THE EFFECT OF LONG-TERM ANTIBIOTIC THERAPY ON THE ANTIBIOTIC RESISTANCE OF THE SALIVARY FLORA. J Oral Ther Pharmacol. 1964 Jul;1:23–44. [PubMed] [Google Scholar]
  10. Handelman S. L., Hawes R. R. The effect of long-term systemic antibiotic administration on the numbers of salivary organisms. Arch Oral Biol. 1965 May-Jun;10(3):353–360. doi: 10.1016/0003-9969(65)90102-0. [DOI] [PubMed] [Google Scholar]
  11. Handelman S. L., Mills J. R., Hawes R. R. Caries incidence in subjects receiving long term antibiotic therapy. J Oral Ther Pharmacol. 1966 Mar;2(5):338–345. [PubMed] [Google Scholar]
  12. Ikeda T., Sandham H. J., Bradley E. L., Jr Changes in Streptococcus mutans and lactobacilli in plaque in relation to the initiation of dental caries in Negro children. Arch Oral Biol. 1973 Apr;18(4):555–566. doi: 10.1016/0003-9969(73)90076-9. [DOI] [PubMed] [Google Scholar]
  13. Jordan H. V., Krasse B., Möller A. A method of sampling human dental plaque for certain "caries-inducing" streptococci. Arch Oral Biol. 1968 Aug;13(8):919–927. doi: 10.1016/0003-9969(68)90007-1. [DOI] [PubMed] [Google Scholar]
  14. KRASSE B. The relationship between lactobacilli, Candida and streptococci and dental caries; examination of saliva and plaque material collected on the same occasion. Odontol Revy. 1954;5(4):241–261. [PubMed] [Google Scholar]
  15. LITTLETON N. W., WHITE C. L. DENTAL FINDINGS FROM A PRELIMINARY STUDY OF CHILDREN RECEIVING EXTENDED ANTIBIOTIC THERAPY. J Am Dent Assoc. 1964 Apr;68:520–525. doi: 10.14219/jada.archive.1964.0111. [DOI] [PubMed] [Google Scholar]
  16. Perch B., Kjems E., Ravn T. Biochemical and serological properties of Streptococcus mutans from various human and animal sources. Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Jun;82(3):357–370. doi: 10.1111/j.1699-0463.1974.tb02338.x. [DOI] [PubMed] [Google Scholar]
  17. Rogers A. H. The proportional distribution and characteristics of streptococci in human dental plaque. Caries Res. 1969;3(3):238–248. doi: 10.1159/000259598. [DOI] [PubMed] [Google Scholar]
  18. Spencer W. H., 3rd, Thornsberry C., Moody M. D., Wenger N. K. Rheumatic fever chemoprophylaxis and penicillin-resistant gingival organisms. Ann Intern Med. 1970 Nov;73(5):683–687. doi: 10.7326/0003-4819-73-5-683. [DOI] [PubMed] [Google Scholar]
  19. Syed S. A., Loesche W. J. Survival of human dental plaque flora in various transport media. Appl Microbiol. 1972 Oct;24(4):638–644. doi: 10.1128/am.24.4.638-644.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. WOOD H. F., STOLLERMAN G. H., FEINSTEIN A. R., HIRSCHFELD I., RUSOFF J. H., TARANTA A., HAAS R. C., EPSTEIN J. A. A controlled study of three methods of prophylaxis against streptococcal infection in a population of rheumatic children. I. Streptococcal infections and recurrences of acute rheumatic fever in the first two years of the study. N Engl J Med. 1957 Aug 29;257(9):394–398. doi: 10.1056/NEJM195708292570902. [DOI] [PubMed] [Google Scholar]
  21. Weld H. G., Sandham H. J. In vitro effects of low concentrations of penicillin and sulfadiazine on Streptococcus mutans. Antimicrob Agents Chemother. 1976 Aug;10(2):196–199. doi: 10.1128/aac.10.2.196. [DOI] [PMC free article] [PubMed] [Google Scholar]

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