Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

Original citation: J Clin Invest. 2011;121(11):4289–4302. doi:10.1172/JCI45144.

Citation for this retraction: J Clin Invest. 2014;124(12):5521. doi:10.1172/JCI79606.

The JCI, with the agreement of the corresponding authors and coauthors, is retracting the article “Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.” The IP: streptavidin/IB: anti-HDAC2 immunoblot panel in Figure 3B was recently identified as an inverted image of the right four lanes of the anti-H4 acetyl CHIP gel presented in Figure 2A. Additionally, the IP: anti-streptavidin/IB: anti-DDK immunoblot presented in Supplemental Figure 3A was identified as an inverted image of the left four lanes of the anti-H4 acetyl CHIP gel presented in Figure 2A. Further, in Figure 9B, the incorrect anti-HDAC2 immunoblot was presented. The authors sincerely apologize for any misinterpretation of the data as a result of these errors.