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. 1976 Aug;10(2):219–222. doi: 10.1128/aac.10.2.219

Comparative Study of Seven Cephalosporins: Susceptibility to Beta-Lactamases and Ability to Penetrate the Surface Layers of Escherichia coli

M H Richmond 1, Sandra Wotton 1
PMCID: PMC429724  PMID: 791093

Abstract

The properties of cefazolin, cefoxitin, cefamandole, and cefuroxime have been compared with those of cephaloridine, cephalothin, and cephalexin. The properties included for examination are the susceptibility to a range of β-lactamases commonly encountered in gram-negative species and the ability of a β-lactam antibiotic to penetrate the outer layers of Escherichia coli. Of the antibiotics tested, cefamandole was the most active in its antibiotic activity but had the disadvantage that it was sensitive to hydrolysis by type IVc β-lactamase. Cefoxitin and cefuroxime were slightly less active than cefamandole but were effectively resistant to all the β-lactamases used in the test.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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