Abstract
The in vitro susceptibility of 145 anaerobic clinical isolates and 96 gram-positive aerobic clinical isolates to josamycin, a new macrolide antibiotic, was studied using the agar dilution technique. Ninety-five of the aerobes were susceptible to 1.56 μg or less of josamycin per ml. The median minimal inhibitory concentration of these organisms was ≤0.39 μg/ml. The in vitro activity of josamycin against the anaerobes was compared with that of erythromycin, clindamycin, penicillin, and chloramphenicol. At concentrations ≤3.12 μg/ml, 100% of strains of Bacteroides species and Bacteroides fragilis were susceptible to josamycin. At low concentrations (≤0.39 μg/ml), clindamycin was more active than josamycin against the anaerobes. However, at concentrations ≤3.12 μg/ml, the activities of josamycin and clindamycin were similar except against the Fusobacterium species, which was quite resistant to josamycin.
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- Finegold S. M., Bartlett J. G., Chow A. W., Flora D. J., Gorbach S. L., Harder E. J., Tally F. P. Management of anaerobic infections. Ann Intern Med. 1975 Sep;83(3):375–389. doi: 10.7326/0003-4819-83-3-375. [DOI] [PubMed] [Google Scholar]
- Frankel R. I. Clindamycin--efficacy and toxicity. West J Med. 1975 Jun;122(6):526–530. [PMC free article] [PubMed] [Google Scholar]
- Gorbach S. L., Bartlett J. G. Anaerobic infections. 1. N Engl J Med. 1974 May 23;290(21):1177–1184. doi: 10.1056/NEJM197405232902106. [DOI] [PubMed] [Google Scholar]
- Keeffe E. B., Katon R. M., Chan T. T., Melnyk C. S., Benson J. A., Jr Pseudomembranous enterocolitis. Resurgence related to newer antibiotic therapy. West J Med. 1974 Dec;121(6):462–472. [PMC free article] [PubMed] [Google Scholar]
- Marr J. J., Sans M. D., Tedesco F. J. Bacterial studies of Clindamycin-associated colitis. A preliminary report. Gastroenterology. 1975 Aug;69(2):352–358. [PubMed] [Google Scholar]
- Strausbaugh L. J., Dilworth J. A., Gwaltney J. M., Jr, Sande M. A. In vitro susceptibility studies with josamycin and erythromycin. Antimicrob Agents Chemother. 1976 Mar;9(3):546–548. doi: 10.1128/aac.9.3.546. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tedesco F. J., Barton R. W., Alpers D. H. Clindamycin-associated colitis. A prospective study. Ann Intern Med. 1974 Oct;81(4):429–433. doi: 10.7326/0003-4819-81-4-429. [DOI] [PubMed] [Google Scholar]
- Yunis A. A. Chloramphenicol-induced bone marrow suppression. Semin Hematol. 1973 Jul;10(3):225–234. [PubMed] [Google Scholar]