Table 6.

Pharmacokinetic parameters of five steroid saponins in rats after single oral administration of total extract from Dioscorea zingiberensis C.H.Wright (n=6, mean ± SD).

Parameters	Protodioscin	Huangjiangsu A	Zingiberensis newsaponins	Dioscin	Gracillin
Cmax (ng mL−1)	29.18 ± 1.83	14.87 ± 1.46	14.87 ± 1.46	38.24 ± 0.63	130.86 ± 1.90
Tmax (h)	11.98 ± 2.45	11.43 ± 3.24	10.32 ± 2.17	10.29 ± 1.19	12.79 ± 2.49
t1/2 (h)	15.86 ± 2.13	11.04 ± 2.03	17.04 ± 2.03	12.79 ± 1.66	37.29 ± 1.82
ke (h−1)	0.044 ± 1.01	0.063 ± 1.98	0.041 ± 3.32	0.054 ± 2.84	0.019 ± 3.72
MRT (h)	18.15 ± 1.83	21.06 ± 2.30	48.61 ± 1.73	25.87 ± 0.74	57.99 ± 1.15
CL (L h−1)	0.21 ± 0.02	0.23 ± 0.02	0.06 ± 0.004	0.11 ± 0.01	0.01 ± 0.003
AUC0-t (h ng mL−1)	6473.11 ± 821.05	291.31 ± 21.14	291.31 ± 21.14	19990.91 ± 727.16	106902.70 ± 2118.13
AUC0-∞ (h ng mL−1)	9098.37 ± 1656.58	3 6747.44 ± 1504.58	6747.44 ± 1504.58	28379.48 ± 2066.52	469583.7 ± 24463.47