Abstract
Virazole (Ribavirin, ICN 1229), a broad-spectrum, antiviral chemotherapeutic agent was used to treat two adult chronically hepatitis B surface antigen (HBs Ag)-seropositive chimpanzees. No significant change in serum hepatitis B surface antigen was noted and no adverse reactions were observed. The role of viral replication in the chronic carrier state of hepatitis B is discussed.
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Selected References
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- Almeida J. D., Rubenstein D., Stott E. J. New antigen-antibody system in Australia-antigen-positive hepatitis. Lancet. 1971 Dec 4;2(7736):1225–1227. doi: 10.1016/s0140-6736(71)90543-5. [DOI] [PubMed] [Google Scholar]
- Barker L. F., Chisari F. V., McGrath P. P., Dalgard D. W., Kirschstein R. L., Almeida J. D., Edington T. S., Sharp D. G., Peterson M. R. Transmission of type B viral hepatitis to chimpanzees. J Infect Dis. 1973 Jun;127(6):648–662. doi: 10.1093/infdis/127.6.648. [DOI] [PubMed] [Google Scholar]
- Berquist K. R., Peterson J. M., Murphy B. L., Ebert J. W., Maynard J. E., Purcell R. H. Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus. Infect Immun. 1975 Sep;12(3):602–605. doi: 10.1128/iai.12.3.602-605.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brzosko W. J., Madaliński K., Krawczyński K., Nowoslawski A. Duality of hepatitis B antigen and its antibody. I. Immunofluorescence studies. J Infect Dis. 1973 Apr;127(4):424–428. doi: 10.1093/infdis/127.4.424. [DOI] [PubMed] [Google Scholar]
- Huang S. N., Millman I., O'Connell A., Aronoff A., Gault H., Blumberg B. S. Virus-like particles in Australia antigen-associated hepatitis. An immunoelectron microscopic study of human liver. Am J Pathol. 1972 Jun;67(3):453–470. [PMC free article] [PubMed] [Google Scholar]
- Ling C. M., Overby L. R. Prevalence of hepatitis B virus antigen as revealed by direct radioimmune assay with 125 I-antibody. J Immunol. 1972 Oct;109(4):834–841. [PubMed] [Google Scholar]
- Sidwell R. W., Huffman J. H., Khare G. P., Allen L. B., Witkowski J. T., Robins R. K. Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science. 1972 Aug 25;177(4050):705–706. doi: 10.1126/science.177.4050.705. [DOI] [PubMed] [Google Scholar]
- Streeter D. G., Witkowski J. T., Khare G. P., Sidwell R. W., Bauer R. J., Robins R. K., Simon L. N. Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1174–1178. doi: 10.1073/pnas.70.4.1174. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zuñiga C. B., de Almeida C., Iervolino A. C., Castro I. de O., Galvão P. A. Aço do 1-beta-D-ribofuranosyl, 1,2,4-triazol-3-carboxamida no tratamento das hepatites virais agudas. AMB Rev Assoc Med Bras. 1974 Nov;20(11):386–390. [PubMed] [Google Scholar]
