Abstract
The pharmacology of cefamandole in seven patients with stable renal insufficiency and in eight patients undergoing hemodialysis was determined. All patients had creatinine clearances less than 5 ml/min. The half-life of cefamandole in those patients with stable chronic renal failure was 7.7 ± 2.2 h. The mean venous level 1 h after intravenous injection of a 1-g dose was 85.3 ± 32.0 μg/ml. The mean venous half-life of cefamandole during hemodialysis was 6.1 h. The venous serum level after 5.5 of hemodialysis was 50.4 ± 20.8 μg/ml. The mean coefficient of extraction was 0.155, and the mean clearance was 34.7 ml/min. The time interval between doses of cefamandole administered intravenously should be lengthened to 24 h in the presence of stable renal failure. No major change in dosage schedule is necessary for patients undergoing dialysis.
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Selected References
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- Eykyn S., Jenkins C., King A., Phillips I. Antibacterial activity of cefamandole, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cephalexin. Antimicrob Agents Chemother. 1973 Jun;3(6):657–661. doi: 10.1128/aac.3.6.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fong I. W., Ralph E. D., Engelking E. R., Kirby W. M. Clinical pharmacology of cefamandole as compared with cephalothin. Antimicrob Agents Chemother. 1976 Jan;9(1):65–69. doi: 10.1128/aac.9.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meyers B. R., Ribner B., Yancovitz S., Hirschman S. Z. Pharmacological studies with cefamandole in human volunteers. Antimicrob Agents Chemother. 1976 Jan;9(1):140–144. doi: 10.1128/aac.9.1.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moellering R. C., Jr, Swartz M. N. Drug therapy: The newer cephalosporins. N Engl J Med. 1976 Jan 1;294(1):24–28. doi: 10.1056/NEJM197601012940106. [DOI] [PubMed] [Google Scholar]
- Neu H. C. Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity. Antimicrob Agents Chemother. 1974 Aug;6(2):177–182. doi: 10.1128/aac.6.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu H. C. Guidelines to antibiotic therapy in renal failure. Med Times. 1973 Nov;101(11):47–52. [PubMed] [Google Scholar]
- Nightingale C. H., Greene D. S., Quintiliani R. Pharmacokinetics and clinical use of cephalosporin antibiotics. J Pharm Sci. 1975 Dec;64(12):1899–1926. doi: 10.1002/jps.2600641202. [DOI] [PubMed] [Google Scholar]
- Shemonsky N. K., Carrizosa J., Levison M. E. In vitro activity and pharmacokinetics in patients of cefamandole, a new cephalsoporin antibiotic. Antimicrob Agents Chemother. 1975 Dec;8(6):679–683. doi: 10.1128/aac.8.6.679. [DOI] [PMC free article] [PubMed] [Google Scholar]