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. 1976 Oct;10(4):626–629. doi: 10.1128/aac.10.4.626

Nosocomial Infection with Gentamicin-Carbenicillin-Resistant Pseudomonas aeruginosa

Ian M Baird *, Jerry M Slepack †,1, Carol A Kauffman †, John P Phair †
PMCID: PMC429805  PMID: 825033

Abstract

Pseudomonas aeruginosa resistant to both gentamicin and carbenicillin was isolated with increasing frequency at the Cincinnati Veterans Administration Hospital during the period 1971 to 1974. A comparison of patients from whom P. aeruginosa was isolated during this period failed to reveal any significant clinical differences between the patients colonized or infected with resistant organisms and those colonized or infected with susceptible organisms. Overt clinical infection attributable to either organism was rare. The antibiotic-resistant organisms were isolated most frequently from urine. Isolation of the antibiotic-resistant organisms was more frequent from patients who had previously received gentamicin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barry A. L., Garcia F., Thrupp L. D. An improved single-disk method for testing the antibiotic susceptibility of rapidly-growing pathogens. Am J Clin Pathol. 1970 Feb;53(2):149–158. doi: 10.1093/ajcp/53.2.149. [DOI] [PubMed] [Google Scholar]
  2. Chadwick P. Resistance of Pseudomonas aeruginosa to gentamicin. Can Med Assoc J. 1973 Oct 6;109(7):585–587. [PMC free article] [PubMed] [Google Scholar]
  3. Farmer J. J., 3rd Pseudomonas in the hospital. Hosp Pract. 1976 Feb;11(2):63–70. doi: 10.1080/21548331.1976.11706501. [DOI] [PubMed] [Google Scholar]
  4. Feingold D. S. Hospital-acquired infections. N Engl J Med. 1970 Dec 17;283(25):1384–1391. doi: 10.1056/NEJM197012172832507. [DOI] [PubMed] [Google Scholar]
  5. Fekety R. F., Jr Nosocomial infections. Postgrad Med. 1971 Nov;50(5):115–119. doi: 10.1080/00325481.1971.11697668. [DOI] [PubMed] [Google Scholar]
  6. Finland M. Changing patterns of susceptibility of common bacterial pathogens to antimicrobial agents. Ann Intern Med. 1972 Jun;76(6):1009–1036. doi: 10.7326/0003-4819-76-6-1009. [DOI] [PubMed] [Google Scholar]
  7. Gaman W., Cates C., Snelling C. F., Lank B., Ronald A. R. Emergence of gentamicin- and carbenicillin-resistant Pseudomonas aeruginosa in a hospital environment. Antimicrob Agents Chemother. 1976 Mar;9(3):474–480. doi: 10.1128/aac.9.3.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Greene W. H., Moody M., Schimpff S., Young V. M., Wiernik P. H. Pseudomonas aeruginosa resistant to carbenicillin and gentamicin. Epidemiologic and clinical aspects in a cancer center. Ann Intern Med. 1973 Nov;79(5):684–689. doi: 10.7326/0003-4819-79-5-684. [DOI] [PubMed] [Google Scholar]
  9. Knothe H., Krcméry V., Sietzen W., Borst J. Transfer of gentamicin resistance from Pseudomonas aeruginosa strains highly resistant to gentamicin and carbenicillin. Chemotherapy. 1973;18(4):229–234. doi: 10.1159/000221266. [DOI] [PubMed] [Google Scholar]
  10. Korfhagen T. R., Loper J. C., Ferrel J. A. Pseudomonas aeruginosa R factors determining gentamicin plus carbenicillin resistance from patients with urinary tract colonizations. Antimicrob Agents Chemother. 1975 Jan;7(1):64–68. doi: 10.1128/aac.7.1.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Korfhagen T. R., Loper J. C. RPL11, an R factor of Pseudomonas aeruginosa determining carbenicillin and gentamicin resistance. Antimicrob Agents Chemother. 1975 Jan;7(1):69–73. doi: 10.1128/aac.7.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Levine A. S., Graw R. G., Jr, Young R. C. Management of infections in patients with leukemia and lymphoma: current concepts and experimental approaches. Semin Hematol. 1972 Apr;9(2):141–179. [PubMed] [Google Scholar]
  13. Meyer R. D., Lewis R. P., Halter J., White M. Gentamicin-resistant Pseudomonas aeruginosa and Serratia marcescens in a general hospital. Lancet. 1976 Mar 13;1(7959):580–583. doi: 10.1016/s0140-6736(76)90370-6. [DOI] [PubMed] [Google Scholar]
  14. Schimpff S. C., Young V. M., Greene W. H., Vermeulen G. D., Moody M. R., Wiernik P. H. Origin of infection in acute nonlymphocytic leukemia. Significance of hospital acquisition of potential pathogens. Ann Intern Med. 1972 Nov;77(5):707–714. doi: 10.7326/0003-4819-77-5-707. [DOI] [PubMed] [Google Scholar]
  15. Slepack J. M., Korfhagen T., Loper J. C., Tan J. S., Phair J. P. Virulence in rats of gentamicin-carbenicillin-resistant Pseudomonas. Antimicrob Agents Chemother. 1975 Oct;8(4):513–514. doi: 10.1128/aac.8.4.513. [DOI] [PMC free article] [PubMed] [Google Scholar]

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