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. 1976 Oct;10(4):657–663. doi: 10.1128/aac.10.4.657

Comparison of the Antibacterial Activity of Nine Cephalosporins Against Enterobacteriaceae and Nonfermentative Gram-Negative Bacilli

Ludo Verbist 1
PMCID: PMC429810  PMID: 984801

Abstract

The in vitro antibacterial activity of nine cephalosporins (cephalothin, cephaloridine, cephalexin, cefazolin, cefamandole, cefuroxime, cefatrizine, cefoxitin, and cefazaflur) was determined against 344 strains of Enterobacteriaceae and 99 nonfermentative gram-negative bacilli. Cefamandole, cefazaflur, and cefuroxime were the most active cephalosporins against the Enterobacteriaceae (with the exception of Serratia marcescens). However, cefoxitin was the only cephalosporin that inhibited all 30 S. marcescens strains in a concentration of 16 μg/ml and was by far the most active compound against selected cephalothin-resistant strains of Escherichia coli, Klebsiella, and Proteus mirabilis. Acinetobacter spp. were inhibited best by cefuroxime, but none of the cephalosporins had appreciable activity against the Pseudomonas spp.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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