Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1976 Oct;10(4):677–681. doi: 10.1128/aac.10.4.677

In Vitro Susceptibility of Gentamicin-Resistant Enterobacteriaceae and Pseudomonas aeruginosa to Netilmicin and Selected Aminoglycoside Antibiotics

Richard D Meyer *, Linda L Kraus †, Karen A Pasiecznik †
PMCID: PMC429813  PMID: 825036

Abstract

Netilmicin (Sch 20569), a semisynthetic aminoglycoside related to gentamicin C1a, was evaluated in vitro in agar dilution testing against 224 different clinical isolates of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa in parallel with amikacin, gentamicin, sisomicin, and tobramycin. Netilmicin showed a very high degree of activity against gentamicin-resistant organisms, but amikacin was more active in vitro, particularly against Providencia stuartii and P. aeruginosa. Sisomicin and tobramycin were consistently less active than either netilmicin or amikacin. Netilmicin was bactericidal in broth testing against P. aeruginosa. Netilmicin showed a greater difference between results with agar and broth dilution testing than did amikacin.

Full text

PDF
677

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  2. Benveniste R., Davies J. Mechanisms of antibiotic resistance in bacteria. Annu Rev Biochem. 1973;42:471–506. doi: 10.1146/annurev.bi.42.070173.002351. [DOI] [PubMed] [Google Scholar]
  3. Finland M. Changing patterns of susceptibility of common bacterial pathogens to antimicrobial agents. Ann Intern Med. 1972 Jun;76(6):1009–1036. doi: 10.7326/0003-4819-76-6-1009. [DOI] [PubMed] [Google Scholar]
  4. Gaman W., Cates C., Snelling C. F., Lank B., Ronald A. R. Emergence of gentamicin- and carbenicillin-resistant Pseudomonas aeruginosa in a hospital environment. Antimicrob Agents Chemother. 1976 Mar;9(3):474–480. doi: 10.1128/aac.9.3.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Garrod L. P., Waterworth P. M. Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin. J Clin Pathol. 1969 Sep;22(5):534–538. doi: 10.1136/jcp.22.5.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Klastersky J., Bogaerts A. M., Noterman J., van Laer E., Daneau D., Mouawad E. Infections caused by Providence bacilli. Scand J Infect Dis. 1974;6(2):153–160. doi: 10.3109/inf.1974.6.issue-2.09. [DOI] [PubMed] [Google Scholar]
  7. Lewis R. P., Meyer R. D., Kraus L. L. Antibacterial activity of selected beta-lactam and aminoglycoside antibiotics against cephalothin-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 1976 May;9(5):780–786. doi: 10.1128/aac.9.5.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McGowan J. E., Jr, Garner C., Wilcox C., Finland M. Antibiotic susceptibility of gram-negative bacilli isolated from blood cultures. Results of tests with 35 agents and strains from 169 patients at Boston City Hospital during 1972. Am J Med. 1974 Aug;57(2):225–238. doi: 10.1016/0002-9343(74)90447-1. [DOI] [PubMed] [Google Scholar]
  9. Medeiros A. A., O'Brien T. F., Wacker W. E., Yulug N. F. Effect of salt concentration on the apparent in-vitro susceptibility of Pseudomonas and other gram-negative bacilli to gentamicin. J Infect Dis. 1971 Dec;124 (Suppl):S59–S64. doi: 10.1093/infdis/124.supplement_1.s59. [DOI] [PubMed] [Google Scholar]
  10. Meyer R. D., Lewis R. P., Carmalt E. D., Finegold S. M. Amikacin therapy for serious gram-negative bacillary infections. Ann Intern Med. 1975 Dec;83(6):790–800. doi: 10.7326/0003-4819-83-6-790. [DOI] [PubMed] [Google Scholar]
  11. Meyer R. D., Lewis R. P., Halter J., White M. Gentamicin-resistant Pseudomonas aeruginosa and Serratia marcescens in a general hospital. Lancet. 1976 Mar 13;1(7959):580–583. doi: 10.1016/s0140-6736(76)90370-6. [DOI] [PubMed] [Google Scholar]
  12. Meyer R. D., Young L. S., Armstrong D. Tobramycin (nebramycin factor 6): in vitro activity against Pseudomonas aeruginosa. Appl Microbiol. 1971 Dec;22(6):1147–1151. doi: 10.1128/am.22.6.1147-1151.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Overturf G. D., Wilkins J., Ressler R. Emergence of resistance of Providencia stuartii to multiple antibiotics: speciation and biochemical characterization of Providencia. J Infect Dis. 1974 Mar;129(3):353–357. doi: 10.1093/infdis/129.3.353. [DOI] [PubMed] [Google Scholar]
  14. Rahal J. J., Jr, Simberkoff M. S., Kagan K., Moldover N. H. Bactericidal efficacy of Sch 20569 and amikacin against gentamicin-sensitive and -resistant organisms. Antimicrob Agents Chemother. 1976 Apr;9(4):595–599. doi: 10.1128/aac.9.4.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Traub W. H. Susceptibility of Pseudomonas aeruginosa to gentamicin sulfate in vitro: lack of correlation between disc diffusion and broth dilution sensitivity data. Appl Microbiol. 1970 Jul;20(1):98–102. doi: 10.1128/am.20.1.98-102.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Weinstein R. J., Young L. S., Hewitt W. L. Activity of three aminoglycosides and two penicillins against four species of gram-negative bacilli. Antimicrob Agents Chemother. 1975 Feb;7(2):172–178. doi: 10.1128/aac.7.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Young L. S., Hewitt W. L. Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus. Antimicrob Agents Chemother. 1973 Dec;4(6):617–625. doi: 10.1128/aac.4.6.617. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES