Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1976 Oct;10(4):770–772. doi: 10.1128/aac.10.4.770

Therapeutic Effects of Small-Particle Aerosols of Ribavirin on Parainfluenza (Sendai) Virus Infections of Mice

E W Larson a, E L Stephen a, J S Walker a,1
PMCID: PMC429828  PMID: 185954

Abstract

Small-particle aerosol administration of ribavirin (1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide) increased survival rates, extended the time to death, delayed lung pathology, and reduced pulmonary virus levels in Sendai virus-infected mice.

Full text

PDF
770

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appell L. H., Kovatch R. M., Reddecliff J. M., Gerone P. J. Pathogenesis of Sendai virus infection in mice. Am J Vet Res. 1971 Nov;32(11):1835–1841. [PubMed] [Google Scholar]
  2. Huffman J. H., Sidwell R. W., Khare G. P., Witkowski J. T., Allen L. B., Robins R. K. In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob Agents Chemother. 1973 Feb;3(2):235–241. doi: 10.1128/aac.3.2.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Jakab G. J., Dick E. C. Synergistic effect in viral-bacterial infection: combined infection of the murine respiratory tract with Sendai virus and Pasteurella pneumotropica. Infect Immun. 1973 Nov;8(5):762–768. doi: 10.1128/iai.8.5.762-768.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Parker J. C., Reynolds R. K. Natural history of Sendai virus infection in mice. Am J Epidemiol. 1968 Jul;88(1):112–125. doi: 10.1093/oxfordjournals.aje.a120859. [DOI] [PubMed] [Google Scholar]
  5. Robinson T. W., Cureton R. J., Heath R. B. The pathogenesis of Sendai virus infection in the mouse lung. J Med Microbiol. 1968 Aug;1(1):89–95. doi: 10.1099/00222615-1-1-89. [DOI] [PubMed] [Google Scholar]
  6. Sidwell R. W., Huffman J. H., Khare G. P., Allen L. B., Witkowski J. T., Robins R. K. Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science. 1972 Aug 25;177(4050):705–706. doi: 10.1126/science.177.4050.705. [DOI] [PubMed] [Google Scholar]
  7. Stephen E. L., Dominik J. W., Moe J. B., Spertzel R. O., Walker J. S. Treatment of influenza infection of mice by using rimantadine hydrochlorides by the aerosol and intraperitoneal routes. Antimicrob Agents Chemother. 1975 Aug;8(2):154–158. doi: 10.1128/aac.8.2.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Tyrrell D. A., Coid C. R. Sendai virus infection of rats as a convenient model of acute respiratory infection. Vet Rec. 1970 Feb 7;86(6):164–165. doi: 10.1136/vr.86.6.164. [DOI] [PubMed] [Google Scholar]
  9. Walker J. S., Stephen E. L., Spertzel R. O. Small-particle aerosols of antiviral compounds in treatment of type A influenza pneumonia in mice. J Infect Dis. 1976 Jun;133 (Suppl):A140–A144. doi: 10.1093/infdis/133.supplement_2.a140. [DOI] [PubMed] [Google Scholar]
  10. van Nunen M. C., van der Veen J. Experimental infection with Sendai virus in mice. Arch Gesamte Virusforsch. 1967;22(3):388–397. doi: 10.1007/BF01242959. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES