Figure 1.

Cofeeding of an SPI diet prevents HFD-induced impairment of bone quality in rats. A, pQCT analysis of the proximal tibial in 4 different diet rats (n = 9 rats). Trabecular BMD (milligrams per cubic centimeter), total BMD, cortical BMD, and total BMC are presented. B, A fourth vertebra compression test was performed, and parameters of peak load and stiffness are presented along with final rat body weights. Data are expressed as means ± SD (n = 9/group). Means with different letters differ significantly from each other at P < .05 using the Tukey-Kramer post hoc test for pairwise comparisons.