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. 1976 Nov;10(5):779–785. doi: 10.1128/aac.10.5.779

Inhibition of Conjugal Transfer of R Plasmids by Pipemidic Acid and Related Compounds

Shinichi Nakamura *, Satoru Inoue †, Masanao Shimizu †, Shizuko Iyobe †, Susumu Mitsuhashi †
PMCID: PMC429837  PMID: 827237

Abstract

It was found that pipemidic acid and related compounds have the common property of inhibiting the conjugal transfer of R plasmids carried by Escherichia coli and Pseudomonas aeruginosa. This inhibition was not due to bactericidal activity of the compounds against donors, recipients, or R+ transconjugants. However, it was correlated inversely with their minimal inhibitory concentrations, depending especially upon sensitivity of donors to the compounds. The inhibition was generally observed in mating systems using various combinations of 14 R plasmids and 9 bacterial strains. The pretreatment of a donor or a recipient strain with pipemidic acid showed only a small inhibitory effect on the transfer of an R plasmid, whereas the presence of the compound during an active mating caused a marked inhibitory effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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