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. 1976 Nov;10(5):814–823. doi: 10.1128/aac.10.5.814

Cefamandole: In Vitro and Clinical Pharmacokinetics

R S Griffith *, H R Black *, G L Brier *, J D Wolny *
PMCID: PMC429842  PMID: 1008540

Abstract

Cefamandole has a broader spectrum and greater potency than the other cephalosporins. It includes Haemophilus influenzae, most strains of Enterobacter, and many strains of indole-positive Proteus and Bacteroides, with a lower minimal inhibitory concentration for Escherichia coli, Klebsiella, etc. Concentrations of drug in the serum after the parenteral injection of cefamandole exceed manyfold the minimal inhibitory concentrations of over 82% of the bacteria studied. Approximately 65 to 85% is excreted in a biologically active form in the urine. This antibiotic offers advantages of antibacterial effectiveness and at the same time retains the safety of penicillin G and cephalothin in animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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