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. 2015 Jan 6;144(2):271–281. doi: 10.1111/imm.12370

Figure 6.

Figure 6

NIM-R5 induces apoptosis in B-cell precursors from bone marrow. (a) Purified B-cell precursors (Pre-pro-B, pro-B, pre-B and immature B) were stimulated for 12 hr in the presence 50 µg/ml anti-CD38 monoclonal antibody (NIM-R5) or an isotype control (rat IgG) antibody. Cells were then stained with annexin-V FITC and propidium iodide (AnV–PI) and analysed by FACS. AnV–IP– Percentage averages ± SD of three independent experiments are shown. (b) Representative dot plots of apoptosis of pre-pro-B cells and (c) immature B cells.