Table 2.
Therapeutic Indices of Lead LDS Compounds Calculated From Experimental IC50/90 and CC50/90 Values
| Compound | Virus | IC50 (μM) | IC90 (μM) | CC50 (μM) | CC90 (μM) | TI(50) | TI(90) |
|---|---|---|---|---|---|---|---|
| LDS21 | J4/JFH-1 | 0.14 | 1.09 | 65.31 | 199.43 | 476.72 | 182.96 |
| J4/JFH-1(L20F) | 0.75 | 2.18 | 87.08 | 91.48 | |||
| H77/JFH-1 | 2.01 | 62.54 | 32.49 | 3.19 | |||
| JFH-1 | 5.4 | 33.71 | 12.09 | 5.92 | |||
| JFH-1(L20F) | 1.098 | 27.92 | 59.48 | 7.14 | |||
| J6/JFH-1 | 2.14 | 19.08 | 30.52 | 10.45 | |||
| S52/JFH-1 | 3.79 | 113.77 | 17.23 | 1.75 | |||
| ED43/JFH-1 | 2.23 | 11.27 | 29.29 | 17.69 | |||
| LDS21.8 | J4/JFH-1 | 0.29 | 0.43 | 101.36 | 280.19 | 349.52 | 651.6 |
| J4/JFH-1(L20F) | 1.22 | 1.89 | 83.08 | 148.25 | |||
| H77/JFH-1 | 7.41 | 46.66 | 13.68 | 6.00 | |||
| JFH-1 | 1.07 | 25.83 | 94.73 | 10.85 | |||
| JFH-1(L20F) | 1.95 | 12.68 | 51.98 | 22.097 | |||
| J6/JFH-1 | 0.596 | 20.04 | 170.07 | 13.98 | |||
| S52/JFH-1 | 0.71 | 24.73 | 142.76 | 11.33 | |||
| ED43/JFH-1 | 0.21 | 9.79 | 482.67 | 28.62 | |||
| LDS21.9 | J4/JFH-1 | 0.34 | 0.51 | 406.44 | 1211.16 | 1195.41 | 2374.82 |
| J4/JFH-1(L20F) | 0.45 | 0.71 | 903.2 | 1705.86 | |||
| H77/JFH-1 | 3.03 | 86.39 | 134.14 | 14.02 | |||
| JFH-1 | 0.82 | 19.82 | 495.66 | 61.11 | |||
| JFH-1(L20F) | 0.44 | 10.83 | 923.73 | 111.83 | |||
| J6/JFH-1 | 1.79 | 16.83 | 227.06 | 71.96 | |||
| S52/JFH-1 | 2.23 | 16.48 | 182.26 | 73.49 | |||
| ED43/JFH-1 | 2.38 | 11.73 | 170.77 | 103.25 |