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. 1977 Aug;12(2):192–194. doi: 10.1128/aac.12.2.192

In Vitro Uptake of Gentamicin by Rat Renal Cortical Tissue

Chen H Hsu 1, Theodore W Kurtz 1, John M Weller 1
PMCID: PMC429883  PMID: 900917

Abstract

The mechanism of gentamicin uptake in vitro by renal cortical slices of rat kidney was investigated. The cortical-slice-uptake ratio of gentamicin concentration in 1.0 g of tissue water to that of 1.0 ml of incubation medium (SW/M) was 1.44 ± 0.04. The uptake of gentamicin was inhibited by 2 × 10−5 M dinitrophenol (SW/M = 1.03 ± 0.04) and by anoxia (SW/M = 1.01 ± 0.04). The results indicate that aerobic phosphorylation is required to transport gentamicin into the cells. The uptake of p-aminohippurate and tetraethylammonium chloride by renal cortical slices was not affected by gentamicin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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