Abstract
In animal studies we investigated the distribution of rosamicin in plasma and urethral and vaginal tissues in rats as well as in urethral and vaginal secretions in dogs. We found concentration ratios between urethral secretion and plasma of 1.9 and between vaginal secretion and plasma of 2.4. The rosamicin concentrations in urethral and vaginal tissue significantly exceeded the levels of all other tissues investigated. Because rosamicin could be valuable for the treatment of bacterial urethritis and the colonization of the vaginal introitus with fecal bacteria in women, it should be investigated clinically in this respect.
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Selected References
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- Elkins I. B., Cox C. E. Perineal, vaginal and urethral bacteriology of young women. I. Incidence of gram-negative colonization. J Urol. 1974 Jan;111(1):88–92. doi: 10.1016/s0022-5347(17)59896-1. [DOI] [PubMed] [Google Scholar]
- Fair W. R., Couch J., Wehner N. Prostatic antibacterial factor. Identity and significance. Urology. 1976 Feb;7(2):169–177. doi: 10.1016/0090-4295(76)90305-8. [DOI] [PubMed] [Google Scholar]
- ODEBLAD E. INTRACAVITARY CIRCULATION OF AQUEOUS MATERIAL IN THE HUMAN VAGINA. Acta Obstet Gynecol Scand. 1964;43:360–368. doi: 10.3109/00016346409162686. [DOI] [PubMed] [Google Scholar]
- Shehata R. Urethral glands in the wall of the female urethra of rats, mice and closely related rodents. Acta Anat (Basel) 1974;90(3):381–387. doi: 10.1159/000144345. [DOI] [PubMed] [Google Scholar]
- Stamey T. A., Condy M. The diffusion and concentration of trimethoprim in human vaginal fluid. J Infect Dis. 1975 Mar;131(3):261–266. doi: 10.1093/infdis/131.3.261. [DOI] [PubMed] [Google Scholar]
- Stamey T. A., Timothy M., Millar M., Mihara G. Recurrent urinary infections in adult women. The role of introital enterobacteria. Calif Med. 1971 Jul;115(1):1–19. [PMC free article] [PubMed] [Google Scholar]
- Wagman G. H., Waitz J. A., Marquez J., Murawaski A., Oden E. M., Testa R. T., Weinstein M. J. A new Micromonospora-produced macrolide antibiotic, rosamicin. J Antibiot (Tokyo) 1972 Nov;25(11):641–646. doi: 10.7164/antibiotics.25.641. [DOI] [PubMed] [Google Scholar]