Abstract
Rosamicin, a new macrolide substance, was investigated in dogs and humans with regard to its usefulness for the treatment of bacterial prostatitis and compared with the well-known macrolide erythromycin. In dogs with normal and experimentally infected prostates, concentration ratios for rosamicin in prostatic secretion, interstitial fluid (obtained from implanted tissue chambers), and tissue were significantly higher than for erythromycin. The difference was even more pronounced in human prostatic tissue, obtained by transurethral resection. With its broad spectrum against many common urinary pathogens, rosamicin seems to be a promising drug for the treatment of acute and chronic bacterial prostatitis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Crowe C. C., Sanders W. E., Jr Rosamicin: evaluation in vitro and comparison with erythromycin and lincomycin. Antimicrob Agents Chemother. 1974 Mar;5(3):272–275. doi: 10.1128/aac.5.3.272. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eickenberg H. U., Waterman N. G., Scharfenberger L. Concentration of antibiotics in renal interstitial fluid: an experimental model. Urol Res. 1975 Dec 30;3(4):165–167. doi: 10.1007/BF00261952. [DOI] [PubMed] [Google Scholar]
- Sutter V. L., Finegold S. M. Rosamicin: in vitro activity against anaerobes and comparison with erythromycin. Antimicrob Agents Chemother. 1976 Feb;9(2):350–351. doi: 10.1128/aac.9.2.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wagman G. H., Waitz J. A., Marquez J., Murawaski A., Oden E. M., Testa R. T., Weinstein M. J. A new Micromonospora-produced macrolide antibiotic, rosamicin. J Antibiot (Tokyo) 1972 Nov;25(11):641–646. doi: 10.7164/antibiotics.25.641. [DOI] [PubMed] [Google Scholar]
- Waitz J. A., Drube C. G., Moss E. L., Jr, Weinstein M. J. Biological studies with rosamicin, a new Micromonospora-produced macrolide antibiotic. J Antibiot (Tokyo) 1972 Nov;25(11):647–652. doi: 10.7164/antibiotics.25.647. [DOI] [PubMed] [Google Scholar]
- Waterman N. G., Kastan L. B. Interstitial fluid and serum antibiotic concentrations. Arch Surg. 1972 Aug;105(2):192–196. doi: 10.1001/archsurg.1972.04180080046008. [DOI] [PubMed] [Google Scholar]