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. 1977 Aug;12(2):255–260. doi: 10.1128/aac.12.2.255

Morphological Changes in Yeasts as a Result of the Action of 5-Fluorocytosine

Tadashi Arai *, Yuzuru Mikami †, Koji Yokoyama †, Tomio Kawata †, Kuniyoshi Masuda †
PMCID: PMC429894  PMID: 332075

Abstract

The mode of action of 5-fluorocytosine on Candida albicans and Saccharomyces cerevisiae was studied with special reference to morphology and ultrastructure. Shortly after contact of yeast cells with 10 μg of 5-fluorocytosine per ml, marked enlargement of the cells occurred. The initial increase in cell size was almost the same with both yeast strains. As incubation proceeded, further increase in cell volume continued with C. albicans, whereas no further change in cell volume was observed with S. cerevisiae. An electron microscope examination of C. albicans cells after exposure to the drug revealed characteristic changes, consisting of an enlarged nucleus and a thin cell wall. The morphological changes were exactly comparable to those reported with inhibitors of deoxyribonucleic acid synthesis in mammalian cells and some bacteria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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