Skip to main content

. 1977 Aug;12(2):284–285. doi: 10.1128/aac.12.2.284

Comparative Stability of Cephalothin and Cefazolin in Buffer or Human Serum

Donald Pitkin ¹, Paul Actor ¹, John J Filan ¹, Roderick White ¹, Jerry A Weisbach ¹

PMCID: PMC429898 PMID: 20044

Abstract

A marked loss in potency was observed when cephalothin was incubated for 5 h in human serum at 37°C. Cefazolin was stable under these conditions.

284

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

Foglesong M. A. Stability of cephalosporins in horse serum. Antimicrob Agents Chemother. 1977 Jan;11(1):174–175. doi: 10.1128/aac.11.1.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
Yamana T., Tsuji A. Comparative stability of cephalosporins in aqueous solution: kinetics and mechanisms of degradation. J Pharm Sci. 1976 Nov;65(11):1563–1574. doi: 10.1002/jps.2600651104. [DOI] [PubMed] [Google Scholar]

ACTIONS

RESOURCES