Abstract
Sisomicin was transformed to gentamicin C2b by Micromonospora rhodorangea NRRL 5326. The mechanisms involved in the biotransformation are the 6′-N-methylation and the (4′-5′)-reduction. The progression of the methylation was followed by the isotope technique, but the reduction reaction was not monitored.
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- Daniels P. J., Jaret R. S., Nagabhushan T. L., Turner W. N. The structure of antibiotic G-52, a new aminocyclitol-aminoglycoside antibiotic produced by Micromonospora zionensis. J Antibiot (Tokyo) 1976 May;29(5):488–491. doi: 10.7164/antibiotics.29.488. [DOI] [PubMed] [Google Scholar]
- Daniels P. J., Luce C., Nagabhushan T. L. The gentamicin antibiotics. 6. Gentamicin C2b, an aminoglycoside antibiotic produced by Micromonospora purpurea mutant JI-33. J Antibiot (Tokyo) 1975 Jan;28(1):35–41. doi: 10.7164/antibiotics.28.35. [DOI] [PubMed] [Google Scholar]
- Lee B. K., Condon R. G., Wagman G. H., Byrne K., Schaffner C. Incorporation of L-methionine-methyl-14C into gentamicins. II. Large-scale preparation of methyl-14C-gentamicins. J Antibiot (Tokyo) 1974 Nov;27(11):822–825. doi: 10.7164/antibiotics.27.822. [DOI] [PubMed] [Google Scholar]
- Lee B. K., Testa R. T., Wagman G. H., Liu C. M., McDaniel L., Schaffner C. Incorporation of L-methionine-methyl-14C into gentamicins. J Antibiot (Tokyo) 1973 Dec;26(12):728–731. doi: 10.7164/antibiotics.26.728. [DOI] [PubMed] [Google Scholar]
- Marquez J. A., Wagman G. H., Testa R. T., Waitz J. A., Weinstein M. J. A new broad spectrum aminoglycoside antibiotic, G-52, produced by Micromonospora zionensis. J Antibiot (Tokyo) 1976 May;29(5):483–487. doi: 10.7164/antibiotics.29.483. [DOI] [PubMed] [Google Scholar]
- Okachi R., Kawamoto I., Takasawa S., Yamamoto M., Sato S. A new antibiotic XK-62-2 (Sagamicin). I. Isolation, physicochemical and antibacterial properties. J Antibiot (Tokyo) 1974 Oct;27(10):793–800. doi: 10.7164/antibiotics.27.793. [DOI] [PubMed] [Google Scholar]
- Testa R. T., Tilley B. C. Biotransformation, a new approach to aminoglycoside biosynthesis: II. Gentamicin. J Antibiot (Tokyo) 1976 Feb;29(2):140–146. doi: 10.7164/antibiotics.29.140. [DOI] [PubMed] [Google Scholar]
- Wagman G. H., Testa R. T., Marquez J. A., Weinstein M. J. Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization. Antimicrob Agents Chemother. 1974 Aug;6(2):144–149. doi: 10.1128/aac.6.2.144. [DOI] [PMC free article] [PubMed] [Google Scholar]