Abstract
The in vitro antifungal activities of amphotericin B (AMB) and amphotericin B methyl ester (AME) were compared against 465 clinical isolates of Candida albicans. AMB and AME possessed comparable activity against half of the strains, but against the remainder of the strains the activity of AME was slightly lower than that of AMB. Rarely did AME show superior antifungal activity to AMB.
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- Bonner D. P., Tewari R. P., Solotorovsky M., Mechlinski W., Schaffner C. P. Comparative chemotherapeutic activity of amphotericin B and amphotericine B methy ester. Antimicrob Agents Chemother. 1975 Jun;7(6):724–729. doi: 10.1128/aac.7.6.724. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bruzzese T., Cambieri M., Recusani F. Synthesis and biological properties of alkyl esters of polyene antibiotics. J Pharm Sci. 1975 Mar;64(3):462–463. doi: 10.1002/jps.2600640327. [DOI] [PubMed] [Google Scholar]
- Gadebusch H. H., Pansy F., Klepner C., Schwind R. Amphotericin B and amphotericin B methyl ester ascorbate. I. Chemotherapeutic activity against Candida albicans, Cryptococcus neoformans, and Blastomyces dermatitidis in mice. J Infect Dis. 1976 Nov;134(5):423–427. doi: 10.1093/infdis/134.5.423. [DOI] [PubMed] [Google Scholar]
- Hamilton-Miller J. M. Chemistry and biology of the polyene macrolide antibiotics. Bacteriol Rev. 1973 Sep;37(3):166–196. [PMC free article] [PubMed] [Google Scholar]
- Howarth W. R., Tewari R. P., Solotorovsky M. Comparative in vitro antifungal activity of amphotericin B and amphotericin B methyl ester. Antimicrob Agents Chemother. 1975 Jan;7(1):58–63. doi: 10.1128/aac.7.1.58. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keim G. R., Jr, Poutsiaka J. W., Kirpan J., Keysser C. H. Amphotericin B methyl ester hydrochloride and amphotericin B: comparative acute toxicity. Science. 1973 Feb 9;179(4073):584–585. doi: 10.1126/science.179.4073.584. [DOI] [PubMed] [Google Scholar]
- Lampen J. O. Amphotericin B and other polyenic antifungal antibiotics. Am J Clin Pathol. 1969 Aug;52(2):138–146. doi: 10.1093/ajcp/52.2.138. [DOI] [PubMed] [Google Scholar]
- Lawrence R. M., Hoeprich P. D. Comparison of amphotericin B and amphotericin B methyl ester: efficacy in murine coccidioidomycosis and toxicity. J Infect Dis. 1976 Feb;133(2):168–174. doi: 10.1093/infdis/133.2.168. [DOI] [PubMed] [Google Scholar]
- Mechlinski W., Schaffner C. P. Polyene macrolide derivatives. I. N-acylation and esterification reactions with amphotericin B. J Antibiot (Tokyo) 1972 Apr;25(4):256–258. [PubMed] [Google Scholar]
- Waksman S. A., Lechevalier H. A., Schaffner C. P. Candicidin and other polyenic antifungal antibiotics. Bull World Health Organ. 1965;33(2):219–226. [PMC free article] [PubMed] [Google Scholar]