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. 1977 Oct;12(4):461–464. doi: 10.1128/aac.12.4.461

Beta-Lactamase Effect on Ampicillin Treatment of Haemophilus influenzae B Bacteremia and Meningitis in Infant Rats

E Richard Moxon 1, Antone A Medeiros †, Thomas F O'Brien 2
PMCID: PMC429946  PMID: 303497

Abstract

Intraperitoneal injections of 250 mg of ampicillin per kg every 6 h for 30 h sterilized the blood and cerebrospinal fluid of infant rats infected with either a β-lactamase-containing strain of Haemophilus influenzae type b or a strain lacking the enzyme. However, a single injection of 100 mg/kg sterilized the blood and cerebrospinal fluid of significantly fewer of those rats infected with the β-lactamase-producing strain. The results suggest that resistance of β-lactamase-containing strains of H. influenzae in vivo may be inoculum dependent, as demonstrated previously in vitro. The infant rat model appears suited for the quantitative delineation of the effect of β-lactamase on the treatment of H. influenzae bacteremia and meningitis with β-lactamase antibiotics.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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