Abstract
Disodium phosphonoacetate (PAA) in a cream-ointment base was applied to herpesvirus skin lesions on the genitalia of cebus monkeys. The lesions had been produced by the intradermal injection of herpes simplex virus type 2. Concentrations of 0.2, 2, and 5% PAA were used. Liberal application of PAA at concentrations of 2 and 5% proved extremely irritating and produced extensive, severe lesions over the treated area. The 2% PAA, when applied carefully to the lesion area, proved less irritating, but did not reduce healing time when compared with the placebo-treated animals. The 0.2% PAA caused slight reduction in lesion size and duration, but these differences were not statistically significant when compared with placebo-treated animals.
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Selected References
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- London W. T., Catalano L. W., Jr, Nahmias A. J., Fuccillo D. A., Sever J. L. Genital herpesvirus hominis Type 2 infection of monkeys. Obstet Gynecol. 1971 Apr;37(4):501–passim. [PubMed] [Google Scholar]
- London W. T., Nahmias A. J., Naib Z. M., Fuccillo D. A., Ellenberg J. H., Sever J. L. A nonhuman primate model for the study of the cervical oncogenic potential of herpes simplex virus type 2. Cancer Res. 1974 May;34(5):1118–1121. [PubMed] [Google Scholar]
- Nahmias A. J., London W. T., Catalano L. W., Fuccillo D. A., Sever J. L., Graham C. Genital herpesvirus hominis type 2 infection: an experimental model in cebus monkeys. Science. 1971 Jan 22;171(3968):297–298. doi: 10.1126/science.171.3968.297. [DOI] [PubMed] [Google Scholar]
- Overby L. R., Robishaw E. E., Schleicher J. B., Rueter A., Shipkowitz N. L., Mao J. C. Inhibition of herpes simplex virus replication by phosphonoacetic acid. Antimicrob Agents Chemother. 1974 Sep;6(3):360–365. doi: 10.1128/aac.6.3.360. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reeves W. C., DiGiacomo R. F., Alexander E. R., Lee C. K. Latent Herpesvirus hominis from trigeminal and sacral dorsal root ganglia of Cebus monkeys. Proc Soc Exp Biol Med. 1976 Nov;153(2):258–261. doi: 10.3181/00379727-153-39523. [DOI] [PubMed] [Google Scholar]
- Shipkowitz N. L., Bower R. R., Appell R. N., Nordeen C. W., Overby L. R., Roderick W. R., Schleicher J. B., Von Esch A. M. Suppression of herpes simplex virus infection by phosphonoacetic acid. Appl Microbiol. 1973 Sep;26(3):264–267. doi: 10.1128/am.26.3.264-267.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]