Abstract
The penetration of gentamicin and tobramycin into the synovial fluid of 12 patients with nontraumatic joint effusions was studied. Simultaneous serum and synovial fluid specimens taken after the intramuscular or intravenous administration of an antimicrobial agent were assayed. Synovial fluid levels of antibiotic were >50% of serum levels in all subjects studied. In five patients, synovial fluid levels were equal to or exceeded simultaneous serum values. These results suggest that intra-articular injection of aminoglycoside antibiotics is not necessary in the treatment of infectious arthritis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baciocco E. A., Iles R. L. Ampicillin and kanamycin concentrations in joint fluid. Clin Pharmacol Ther. 1971 Sep-Oct;12(5):858–863. doi: 10.1002/cpt1971125858. [DOI] [PubMed] [Google Scholar]
- Chow A., Hecht R., Winters R. Gentamicin and carbenicillin penetration into the septic joint. N Engl J Med. 1971 Jul 15;285(3):178–179. doi: 10.1056/nejm197107152850318. [DOI] [PubMed] [Google Scholar]
- Klastersky J., Hensgens C., Henri A., Daneau D. Comparative clinical study of tobramycin and gentamicin. Antimicrob Agents Chemother. 1974 Feb;5(2):133–138. doi: 10.1128/aac.5.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marsh D. C., Jr, Matthew E. B., Persellin R. H. Transport of gentamicin into synovial fluid. JAMA. 1974 Apr 29;228(5):607–607. [PubMed] [Google Scholar]
- Nelson J. D. Antibiotic concentrations in septic joint effusions. N Engl J Med. 1971 Feb 18;284(7):349–353. doi: 10.1056/NEJM197102182840702. [DOI] [PubMed] [Google Scholar]
- Parker R. H., Schmid F. R. Antibacterial activity of synovial fluid during therapy of septic arthritis. Arthritis Rheum. 1971 Jan-Feb;14(1):96–104. doi: 10.1002/art.1780140112. [DOI] [PubMed] [Google Scholar]