Abstract
Thymine starvation of Escherichia coli strain C600 thy (R46) eliminated the R plasmid at a frequency of 17%. This was increased fourfold, to 68%, after the same culture was subjected to an additional three cycles of growth followed by thymineless death.
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Selected References
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- Adachi H., Nakano M., Inuzuka M., Tomoeda M. Specific role of sex pili in the effective eliminatory action of sodium dodecyl sulfate on sex and drug resistance factors in Escherichia coli. J Bacteriol. 1972 Mar;109(3):1114–1124. doi: 10.1128/jb.109.3.1114-1124.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Birks J. H., Pinney R. J. Correlation between thymineless elimination and absence of hsp II (EcoRII) specificity in N-group R factors. J Bacteriol. 1975 Mar;121(3):1208–1210. doi: 10.1128/jb.121.3.1208-1210.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dennison S., Baumberg S. Conjugational behaviour of N plasmids in Escherichia coli K12. Mol Gen Genet. 1975 Jul 10;138(4):323–331. doi: 10.1007/BF00264802. [DOI] [PubMed] [Google Scholar]
- MITSUHASHI S., HARADA K., KAMEDA M. Elimination of transmissible drug-resistance by treatment with acriflavin. Nature. 1961 Mar 18;189:947–947. doi: 10.1038/189947a0. [DOI] [PubMed] [Google Scholar]
- Pinney R. J., Bremer K., Smith J. T. R factor elimination by inhibitors of thymidylate synthetase (fluorodeoxyuridine and showdomycin) and the occurrence of single strand breaks in plasmid DNA. Mol Gen Genet. 1974;133(2):163–174. doi: 10.1007/BF00264837. [DOI] [PubMed] [Google Scholar]
- Pinney R. J., Smith J. T. Curing of an R factor Escherichia coli by trimethoprim. Antimicrob Agents Chemother. 1973 Jun;3(6):670–676. doi: 10.1128/aac.3.6.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pinney R. J., Smith J. T. Fertility inhibition of an N group R factor by a group X R factor, R6K. J Gen Microbiol. 1974 Jun;82(2):415–418. doi: 10.1099/00221287-82-2-415. [DOI] [PubMed] [Google Scholar]
- Pinney R. J., Smith J. T. R factor elimination during thymine starvation: effects of inhibition of protein synthesis and readdition of thymine. J Bacteriol. 1972 Aug;111(2):361–367. doi: 10.1128/jb.111.2.361-367.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pinney R. J., Smith J. T. R-factor elimination by thymine starvation. Genet Res. 1971 Oct;18(2):173–177. doi: 10.1017/s001667230001257x. [DOI] [PubMed] [Google Scholar]
- Salisbury V., Hedges R. W., Datta N. Two modes of "curing" transmissible bacterial plasmids. J Gen Microbiol. 1972 May;70(3):443–452. doi: 10.1099/00221287-70-3-443. [DOI] [PubMed] [Google Scholar]
- Tomoeda M., Inuzuka M., Kubo N., Nakamura S. Effective elimination of drug resistance and sex factors in Escherichia coli by sodium dodecyl sulfate. J Bacteriol. 1968 Mar;95(3):1078–1089. doi: 10.1128/jb.95.3.1078-1089.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATANABE T., FUKASAWA T. Episome-mediated transfer of drug resistance in Enterobacteriaceae. II. Elimination of resistance factors with acridine dyes. J Bacteriol. 1961 May;81:679–683. doi: 10.1128/jb.81.5.679-683.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]