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. 1977 Nov;12(5):577–581. doi: 10.1128/aac.12.5.577

Latent Herpes Simplex Virus Infections in Sensory Ganglia of Mice After Topical Treatment with Adenine Arabinoside and Adenine Arabinoside Monophosphate†

Richard J Klein 1,2, Alvin E Friedman-Kien 1,2
PMCID: PMC429979  PMID: 200172

Abstract

Adenine arabinoside (Ara-A) and Ara-A monosphosphate (Ara-AMP) ointments were able to prevent the fatal outcome of herpes simplex virus (HSV)-induced skin infection of the lumbosacral area in hairless mice. Ara-A and Ara-AMP had no irritating effect on the skin, but in a number of animals a protracted healing time of the skin lesions after the treatment was observed. The compounds conferred only a partial protection against the establishment of latent HSV infection in the spinal root ganglia of the treated animals. The immune response, as judged from levels of HSV-specific neutralizing serum antibody titers, was not impaired by the antiviral treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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