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. 1977 Nov;12(5):602–605. doi: 10.1128/aac.12.5.602

Systemic Metabolic Alterations Associated with Repeated Injections of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex

Michael C Powanda 1,†, Myrl L Sammons 1, Edward L Stephen 1
PMCID: PMC429983  PMID: 921256

Abstract

Polyriboinosinic acid-polyribocytidylic acid complexed with poly-1-lysine and injected intramuscularly into rats (0.3 or 3.0 mg/kg) produced fever, altered leukocyte count, slightly depressed plasma zinc, increased amino acid uptake into liver, and increased plasma acute-phase globulins two- to threefold. It is suggested that these systemic metabolic alterations are indicative of a mild inflammatory response to this drug. The metabolic alterations may have to be taken into consideration when polyriboinosinic acid-polyribocytidylic acid complexed with poly-1-lysine is used in therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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