Table 3.

Handling of loss to follow-up

Level	Reason	Consequence
Tooth	Complication	Complications leading to tooth loss will be counted as non-survival. Teeth with complications which allow the retention of the tooth will be count as non-success. Required follow-up treatments will be recorded and survived teeth will be followed up on.
	Lesion treated by other dentist	Tooth will be counted as non-success or non-survival.
	Tooth exfoliation	The last observation will be carried forward.
Patient	Adverse or serious adverse events related to treatment or material	Counteractive measures will be taken and events documented.
		Patient and tooth will be censored and the last observation carried forward.
	The patient cannot be examined (lost to follow-up)	Patient and survived tooth or teeth will be censored and the last observation carried forward.
	The patient decides to withdraw from the study.	Patient and tooth will be censored and the last observation carried forward.
Study	One to four patient(s) show adverse events related to treatment or material	Counteractive measures will be taken and events documented.
		Patient and tooth will be censored and the last observation carried forward. The study will be interrupted.
	More than four patients show adverse events or one patient shows a severe adverse event related to treatment or material	Counteractive measures will be taken and events documented.
		The study will be terminated. All patients and available teeth will be marked as censored and the last observation carried forward.