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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Steroids. 2014 Dec;91:20–31. doi: 10.1016/j.steroids.2014.08.014

Figure.

Figure

Schematic of 3 types of MR ligand selectivity in neurons. Hp: Hippocampal neurons express both MR and GR; endogenous glucocorticoids are the physiological ligand for the MR and 11β-HSD1 is thought to act as a reductase. PVN: Pre-sympathetic neurons of the PVN express only MR, no GR; aldosterone appears to be the physiological ligand for the MR due to dehydrogenase activity of 11β-HSD1 in the absence of H6PD. NTS: Aldosterone target cells of the NTS express MR and 11β-HSD2, an obligate dehydrogenase. ?: preferred ligand for the membrane-associated MR is not certain. ??: whether GR is Expressed GR in aldo-target cells is not certain.