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. 1976 Apr;73(4):1250–1254. doi: 10.1073/pnas.73.4.1250

A differentiation stimulating factor induces cell sensitivity to 3':5'-cyclic AMP pulses in dictyostelium discoideum.

C Klein, M Darmon
PMCID: PMC430240  PMID: 177982

Abstract

During the first few hours of starvation, Dictyostelium discoideum amoebae excrete a macromolecule, probably a glycoprotein, which stimulates cell differentiation to aggregation competence. 3':5'-Cyclic AMP pulses, which mimic the chemotactic signal, and this factor (differentiation stimulating factor) are shown to exert a cooperative effect in inducing cell differentiation. Data suggest that the appearance of the factor determines the moment amoebae become responsive to cyclic AMP pulses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barkley D. S. Adenosine-3',5'-phosphate: identification as acrasin in a species of cellular slime mold. Science. 1969 Sep 12;165(3898):1133–1134. doi: 10.1126/science.165.3898.1133. [DOI] [PubMed] [Google Scholar]
  2. Beug H., Katz F. E., Gerisch G. Dynamics of antigenic membrane sites relating to cell aggregation in Dictyostelium discoideum. J Cell Biol. 1973 Mar;56(3):647–658. doi: 10.1083/jcb.56.3.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bonner J. T., Barkley D. S., Hall E. M., Konijn T. M., Mason J. W., O'Keefe G., 3rd, Wolfe P. B. Acrasin, Acrasinase, and the sensitivity to acrasin in Dictyostelium discoideum. Dev Biol. 1969 Jul;20(1):72–87. doi: 10.1016/0012-1606(69)90005-0. [DOI] [PubMed] [Google Scholar]
  4. Cohen M. H., Robertson A. Wave propagation in the early stages of aggregation of cellular slime molds. J Theor Biol. 1971 Apr;31(1):101–118. doi: 10.1016/0022-5193(71)90124-x. [DOI] [PubMed] [Google Scholar]
  5. Darmon M., Brachet P., Da Silva L. H. Chemotactic signals induce cell differentiation in Dictyostelium discoideum. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3163–3166. doi: 10.1073/pnas.72.8.3163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. ENNIS H. L., SUSSMAN M. Synergistic morphogenesis by mixtures of Dictyostelium discoideum wild-type and aggregateless mutants. J Gen Microbiol. 1958 Apr;18(2):433–449. doi: 10.1099/00221287-18-2-433. [DOI] [PubMed] [Google Scholar]
  7. GERISCH G. [Cell functions and change in cell function in the development of Dictyostelium discoideum. V. Stagespecific cell contact formation and its quantitative evaluation]. Exp Cell Res. 1961 Dec;25:535–554. doi: 10.1016/0014-4827(61)90189-6. [DOI] [PubMed] [Google Scholar]
  8. Gerisch G., Malchow D., Riedel V., Müller E., Every M. Cyclic AMP phosphodiesterase and its inhibitor in slime mould development. Nat New Biol. 1972 Jan 19;235(55):90–92. doi: 10.1038/newbio235090a0. [DOI] [PubMed] [Google Scholar]
  9. Gerisch G., Wick U. Intracellular oscillations and release of cyclic AMP from Dictyostelium cells. Biochem Biophys Res Commun. 1975 Jul 8;65(1):364–370. doi: 10.1016/s0006-291x(75)80102-1. [DOI] [PubMed] [Google Scholar]
  10. Klein C., Darmon M. The relationship of phosphodiesterase to the developmental cycle of Dictyostelium discoideum. Biochem Biophys Res Commun. 1975 Nov 3;67(1):440–447. doi: 10.1016/0006-291x(75)90335-6. [DOI] [PubMed] [Google Scholar]
  11. Klein C. Induction of phosphodiesterase by cyclic adenosine 3':5'-monophosphate in differentiating Dictyostelium discoideum amoebae. J Biol Chem. 1975 Sep 25;250(18):7134–7138. [PubMed] [Google Scholar]
  12. Konijn T. M., Van De Meene J. G., Bonner J. T., Barkley D. S. The acrasin activity of adenosine-3',5'-cyclic phosphate. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1152–1154. doi: 10.1073/pnas.58.3.1152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Novogrodsky A., Katchalski E. Induction of lymphocyte transformation by sequential treatment with neuraminidase and galactose oxidase. Proc Natl Acad Sci U S A. 1973 Jun;70(6):1824–1827. doi: 10.1073/pnas.70.6.1824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Roos W., Nanjundiah V., Malchow D., Gerisch G. Amplification of cyclic-AMP signals in aggregating cells of Dictyostelium discoideum. FEBS Lett. 1975 May 1;53(2):139–142. doi: 10.1016/0014-5793(75)80005-6. [DOI] [PubMed] [Google Scholar]
  15. Shaffer B. M. Secretion of cyclic AMP induced by cyclic AMP in the cellular slime mould Dictyostelium discoideum. Nature. 1975 Jun 12;255(5509):549–552. doi: 10.1038/255549a0. [DOI] [PubMed] [Google Scholar]
  16. Watts D. J., Ashworth J. M. Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture. Biochem J. 1970 Sep;119(2):171–174. doi: 10.1042/bj1190171. [DOI] [PMC free article] [PubMed] [Google Scholar]

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