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. 1976 Apr;73(4):1279–1283. doi: 10.1073/pnas.73.4.1279

Influence of diet on survival of mice.

G Fernandes, E J Yunis, R A Good
PMCID: PMC430247  PMID: 1063408

Abstract

The longevity of mice of the (NZB X NZW)F1 (B/W) strain and the DBA/2f strain of mice is dramatically prolonged by dietary restriction. B/W mice are susceptible to, and die at an early age from, immunocomplex nephritis. Mice of the DBA/2f strain are also relatively short-lived. Restriction of caloric intake prolonged life of B/W mice more than did protein restriction. DBA/2f mice showed prolongation of life when the diet was restricted only with respect to protein. Caloric restriction alone prolonged life less in DBA/2f mice than in B/W mice. These observations show that dietary manipulations have profound effects on immunity functions, including inhibition of the development of life-shortening autoimmune disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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