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. 1976 Apr;73(4):1284–1287. doi: 10.1073/pnas.73.4.1284

Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells.

P Lindahl, I Gresser, P Leary, M Tovey
PMCID: PMC430248  PMID: 1063409

Abstract

Treatment of young and mature mice with potent mouse interferon preparations results in a marked enhancement of the expression of histocompatibility antigens on the surface of thymocytes and splenic lymphocytes as measured by an enhanced absorption of alloantiserum. We postulate that such modifications of the cell surface may reflect an effect of interferon on lymphocyte maturation and may be relevant to the effect of interferon on lymphocyte function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blomgren H., Strander H., Cantell K. Effect of human leukocyte interferon on the response of lymphocytes to mitogenic stimuli in vitro. Scand J Immunol. 1974;3(6):697–705. doi: 10.1111/j.1365-3083.1974.tb01305.x. [DOI] [PubMed] [Google Scholar]
  2. Blomgren H., Svedmyr E. In vitro stimulation of mouse thymus cells by PHA and allogeneic cells. Cell Immunol. 1971 Aug;2(4):285–299. doi: 10.1016/0008-8749(71)90063-3. [DOI] [PubMed] [Google Scholar]
  3. Braun W., Levy H. B. Interferon preparations as modifiers of immune responses. Proc Soc Exp Biol Med. 1972 Dec;141(3):769–773. doi: 10.3181/00379727-141-36868. [DOI] [PubMed] [Google Scholar]
  4. Brodeur B. R., Merigan T. C. Mechanism of the suppressive effect of interferon on antibody synthesis in vivo. J Immunol. 1975 Apr;114(4):1323–1328. [PubMed] [Google Scholar]
  5. Brodeur B. R., Merigan T. C. Suppressive effect of interferon on the humoral immune response to sheep red blood cells in mice. J Immunol. 1974 Oct;113(4):1319–1325. [PubMed] [Google Scholar]
  6. Cerottini J. C., Brunner K. T., Lindahl P., Gresser I. Inhibitory effect of interferon preparations and inducers on the multiplication of transplanted allogeneic spleen cells and syngeneic bone marrow cells. Nat New Biol. 1973 Apr 4;242(118):152–153. doi: 10.1038/newbio242152a0. [DOI] [PubMed] [Google Scholar]
  7. Cerottini J. C., Brunner K. T. Localization of mouse isoantigens on the cell surface as revealed by immunofluorescence. Immunology. 1967 Oct;13(4):395–403. [PMC free article] [PubMed] [Google Scholar]
  8. Chernyakhovskaya I. Y., Slavina E. G., Svet-Moldavsky G. J. Antitumour effect of lymphoid cells activated by interferon. Nature. 1970 Oct 3;228(5266):71–72. doi: 10.1038/228071a0. [DOI] [PubMed] [Google Scholar]
  9. Chester T. J., Paucker K., Merigan T. C. Suppression of mouse antibody producing spleen cells by various interferon preparations. Nature. 1973 Nov 9;246(5428):92–94. doi: 10.1038/246092a0. [DOI] [PubMed] [Google Scholar]
  10. Gisler R. H., Lindahl P., Gresser I. Effects of interferon on antibody synthesis in vitro. J Immunol. 1974 Aug;113(2):438–444. [PubMed] [Google Scholar]
  11. Hirsch M. S., Ellis D. A., Black P. H., Monaco A. P., Wood M. L. Immunosuppressive effects of an interferon preparation in vivo. Transplantation. 1974 Feb;17(2):234–236. doi: 10.1097/00007890-197402000-00014. [DOI] [PubMed] [Google Scholar]
  12. Johnson H. M., Smith B. G., Baron S. Inhibition of the primary in vitro antibody response by interferon preparations. J Immunol. 1975 Jan;114(1 Pt 2):403–409. [PubMed] [Google Scholar]
  13. Lindahl-Magnusson P., Leary P., Gresser I. Interferon inhibits DNA synthesis induced in mouse lymphocyte suspensions by phytohaemagglutinin or by allogeneic cells. Nat New Biol. 1972 May 24;237(73):120–121. doi: 10.1038/newbio237120a0. [DOI] [PubMed] [Google Scholar]
  14. Lindahl P., Leary P., Gresser I. Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells. Proc Natl Acad Sci U S A. 1973 Oct;70(10):2785–2788. doi: 10.1073/pnas.70.10.2785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lindahl P., Leary P., Gresser I. Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proc Natl Acad Sci U S A. 1972 Mar;69(3):721–725. doi: 10.1073/pnas.69.3.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Oie H. K., Gazdar A. F., Buckler C. E., Baron S. High interferon producing line of transformed murine cells. J Gen Virol. 1972 Oct;17(1):107–109. doi: 10.1099/0022-1317-17-1-107. [DOI] [PubMed] [Google Scholar]
  17. Rozes K. R., Lee S. H., Ngan J. Effect of priming on interferon inhibition of con A induced spleen cell blastogenesis. Nat New Biol. 1973 Sep 5;245(140):16–18. doi: 10.1038/newbio245016a0. [DOI] [PubMed] [Google Scholar]
  18. Skurkovich S. V., Klinova E. G., Aleksandrovskaya I. M., Levina N. V., Arkhipova N. A., Bulicheva T. I. Stimulation of transplantation immunity and plasma cell reaction by interferon in mice. Immunology. 1973 Aug;25(2):317–322. [PMC free article] [PubMed] [Google Scholar]
  19. Svet-Moldavsky G. J., Chernyakhovskaya I. J. Interferon and the interaction of allogeneic normal and immune lymphocytes with L-cells. Nature. 1967 Sep 16;215(5107):1299–1300. doi: 10.1038/2151299a0. [DOI] [PubMed] [Google Scholar]
  20. Thorbecke G. J., Friedman-Kien A. E., Vilcek J. Effect of rabbit interferon on immune responses. Cell Immunol. 1974 May;12(2):290–295. doi: 10.1016/0008-8749(74)90081-1. [DOI] [PubMed] [Google Scholar]
  21. Tovey M. G., Begon-Lours J., Gresser I. A method for the large scale production of potent interferon preparations. Proc Soc Exp Biol Med. 1974 Jul;146(3):809–815. doi: 10.3181/00379727-146-38196. [DOI] [PubMed] [Google Scholar]
  22. de Maeyer E., Mobraaten L., de Maeyer-Guignard J. Prolongation par l'interféron de la survie des greffes de peau chez la souris. C R Acad Sci Hebd Seances Acad Sci D. 1973 Nov 12;277(19):2101–2103. [PubMed] [Google Scholar]

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