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Interaction between BA-1 and reduced PDI. The main figure shows a spectrophotometric determination of the net stoichiometry of binding of BA-1 to 10 μM reduced PDI (see Materials and Methods). The inset repeats the titration using 1 μM reduced PDI to provide an estimate of the dissociation constant. The solid curve is fit to a Kd of 54 nM ± 29 nM with a stoichiometry of 0.90 ± 0.08 molecules of the bis-arsenical BA-1 (see Materials and Methods).
