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. 1976 May;73(5):1707–1711. doi: 10.1073/pnas.73.5.1707

Antibody-producing cells: virus-induced alteration of response to antigen.

V Riley, W Braun, M Ishizuka, D Spackman
PMCID: PMC430369  PMID: 1083981

Abstract

Spleen antibody-forming cells of mice yield a 3- to 10-fold increase in their response to sheep erythrocyte antigen if they are acutely infected by lactate dehydrogenase-elevating virus. This early stimulation is replaced by a long-term inhibition of the antibody-forming cells as the viremia goes into its persisting chronic stage. These contrasting immunological phenomena are examined as contributing factors responsible for the enhancement by this virus of asparaginase (EC 3.5.1.1; L-asparagine amidolydrolase) therapy against leukemia in mice, and for the alteration of the susceptibility of mice to various neoplastic processes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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