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. 1976 May;73(5):1725–1729. doi: 10.1073/pnas.73.5.1725

Search for antigens and antibodies crossreactive with type C viruses of the woolly monkeys and gibbon ape in animal models and in humans.

J R Stephenson, S A Aaronson
PMCID: PMC430373  PMID: 179097

Abstract

Several reports have indicated the presence of type-C viral antigens in human tumors and of viruses closely related to those of the woolly monkey and gibbon ape in cultured human cells. In the present studies, attempts to detect woolly monkeys viral antigens in human tissues, or antibodies directed against structural polypeptides of woolly monkey viruses in human sera, were unsuccessful, In contrast, it was possible to demonstrate viral antigens in tissues and antibodies reactive to viral components in several animal and even primate model systems. Further evidence against the presence of woolly monkey viruses in humans is our failure to identify spontaneous or chemically induced viruses of this group in more than 200 individual cultures of human origin examined. These findings argue against the likelihood that viruses closely related to the woolly monkeys virus are associated with human tumors or are common infectious agents of man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benveniste R. E., Heinemann R., Wilson G. L., Callahan R., Todaro G. J. Detection of baboon type C viral sequences in various primate tissues by molecular hybridization. J Virol. 1974 Jul;14(1):56–67. doi: 10.1128/jvi.14.1.56-67.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Benveniste R. E., Lieber M. M., Livingston D. M., Sherr C. J., Todaro G. J., Kalter S. S. Infectious C-type virus isolated from a baboon placenta. Nature. 1974 Mar 1;248(5443):17–20. doi: 10.1038/248017a0. [DOI] [PubMed] [Google Scholar]
  3. Benveniste R. E., Todaro G. J. Evolution of type C viral genes: I. Nucleic acid from baboon type C virus as a measure of divergence among primate species. Proc Natl Acad Sci U S A. 1974 Nov;71(11):4513–4518. doi: 10.1073/pnas.71.11.4513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Benveniste R. E., Todaro G. J. Homology between type-C viruses of various species as determined by molecular hybridization. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3316–3320. doi: 10.1073/pnas.70.12.3316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chapman H. P., White M. H., Rahman R., Gilden R. V. Species and interspecies radioimmunoassays for rat type C virus p30: interviral comparisons and assay of human tumor extracts. J Virol. 1975 Jan;17(1):51–59. doi: 10.1128/jvi.17.1.51-59.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Charman H. P., Kim N., White M., Marquardt H., Gilden R. V., Kawakami T. Natural and experimentally induced antibodies to defined mammalian type-C virus proteins in primates. J Natl Cancer Inst. 1975 Dec;55(6):1419–1424. doi: 10.1093/jnci/55.6.1419. [DOI] [PubMed] [Google Scholar]
  7. Gabelman N., Waxman S., Smith W., Douglas S. D. Appearance of C-type virus-like particles after co-cultivation of a human tumor-cell line with rat (XC) cells. Int J Cancer. 1975 Sep 15;16(3):355–369. doi: 10.1002/ijc.2910160302. [DOI] [PubMed] [Google Scholar]
  8. Gallagher R. E., Gallo R. C. Type C RNA tumor virus isolated from cultured human acute myelogenous leukemia cells. Science. 1975 Jan 31;187(4174):350–353. doi: 10.1126/science.46123. [DOI] [PubMed] [Google Scholar]
  9. Gallagher R. E., Salahuddin S. Z., Hall W. T., McCredie K. B., Gallo R. C. Growth and differentiation in culture of leukemic leukocytes from a patient with acute myelogenous leukemia and re-identification of type-C virus. Proc Natl Acad Sci U S A. 1975 Oct;72(10):4137–4141. doi: 10.1073/pnas.72.10.4137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gallagher R. E., Todaro G. J., Smith R. G., Livingston D. M., Gallo R. C. Relationship between RNA-directed DNA polymerase (reverse transcriptase) from human acute leukemic blood cells and primate type-C viruses. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1309–1313. doi: 10.1073/pnas.71.4.1309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Giard D. J., Aaronson S. A., Todaro G. J., Arnstein P., Kersey J. H., Dosik H., Parks W. P. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst. 1973 Nov;51(5):1417–1423. doi: 10.1093/jnci/51.5.1417. [DOI] [PubMed] [Google Scholar]
  12. Gilden R. V., Toni R., Hanson M., Bova D., Charman H. P., Oroszlan S. Immunochemical studies of the major internal polypeptide of woolly monkey and gibbon ape type C viruses. J Immunol. 1974 Mar;112(3):1250–1254. [PubMed] [Google Scholar]
  13. Hersh E. M., Gutterman J. U., Mavligit G., Gschwind C. R., Freireich E. J., Levine P. H., Plata E. J. Human immune response to active immunization with Rauscher leukemia virus. I. Cell-mediated and cell-associated immunity. J Natl Cancer Inst. 1974 Aug;53(2):317–325. doi: 10.1093/jnci/53.2.317. [DOI] [PubMed] [Google Scholar]
  14. Hino S., Stephenson J. R., Aaronson S. A. Antigenic determinants of the 70,000 molecular weight glycoprotein of woolly monkey type C RNA virus. J Immunol. 1975 Oct;115(4):922–927. [PubMed] [Google Scholar]
  15. JARRETT W. F., MARTIN W. B., CRIGHTON G. W., DALTON R. G., STEWART M. F. TRANSMISSION EXPERIMENTS WITH LEUKEMIA (LYMPHOSARCOMA). Nature. 1964 May 9;202:566–567. doi: 10.1038/202566a0. [DOI] [PubMed] [Google Scholar]
  16. Kalter S. S., Helmke R. J., Panigel M., Heberling R. L., Felsburg P. J., Axelrod L. R. Observations of apparent C-type particles in baboon (Papio cynocephalus) placentas. Science. 1973 Mar 30;179(4080):1332–1333. doi: 10.1126/science.179.4080.1332. [DOI] [PubMed] [Google Scholar]
  17. Kawakami T. G., Buckley P. M. Antigenic studies on gibbon type-C viruses. Transplant Proc. 1974 Jun;6(2):193–196. [PubMed] [Google Scholar]
  18. Kawakami T. G., Huff S. D., Buckley P. M., Dungworth D. L., Synder S. P., Gilden R. V. C-type virus associated with gibbon lymphosarcoma. Nat New Biol. 1972 Feb 9;235(58):170–171. doi: 10.1038/newbio235170a0. [DOI] [PubMed] [Google Scholar]
  19. Kawakami T., Buckley P. M., McDowell T. S., DePaoli A. Antibodies to simian C-type virus antigen in sera of gibbons (Hylobates sp.). Nat New Biol. 1973 Nov 28;246(152):105–107. doi: 10.1038/newbio246105a0. [DOI] [PubMed] [Google Scholar]
  20. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  21. Lieber M. M., Sherr C. J., Todaro G. J., Benveniste R. E., Callahan R., Coon H. G. Isolation from the asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2315–2319. doi: 10.1073/pnas.72.6.2315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Nooter K., Aarssen A. M., Bentvelzen P., De Groot F. G., Van Pelt F. G. Isolation of infectious C-type oncornavirus from human leukaemic bone marrow cells. Nature. 1975 Aug 14;256(5518):595–597. doi: 10.1038/256595a0. [DOI] [PubMed] [Google Scholar]
  23. Okabe H., Gilden R. V., Hatanaka M. Specificity of the DNA product of RNA-dependent DNA polymerase in type C viruses. II. Quantitative analysis. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3923–3927. doi: 10.1073/pnas.70.12.3923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Okabe H., Gilden R. V., Hatanaka M., Stephenson J. R., Gallagher R. E., Aaronson S. A., Gallo R. C., Tronick S. R. Immunological and biochemical characterisation of type C viruses isolated from cultured human AML cells. Nature. 1976 Mar 18;260(5548):264–266. doi: 10.1038/260264a0. [DOI] [PubMed] [Google Scholar]
  25. Panem S., Prochownik E. V., Reale F. R., Kirsten W. H. Isolation of type C virions from a normal human fibroblast strain. Science. 1975 Jul 25;189(4199):297–299. doi: 10.1126/science.49927. [DOI] [PubMed] [Google Scholar]
  26. Parks W. P., Scolnick E. M., Noon M. C., Watson C. J., Kawakami T. G. Radioimmunoassay of mammalian type-C polypeptides. IV. Characterization of woolly monkey and gibbon viral antigens. Int J Cancer. 1973 Jul 15;12(1):129–137. doi: 10.1002/ijc.2910120114. [DOI] [PubMed] [Google Scholar]
  27. Scolnick E. M., Parks W. P., Todaro G. J. Reverse transcriptases of primate viruses as immunological markers. Science. 1972 Sep 22;177(4054):1119–1121. doi: 10.1126/science.177.4054.1119. [DOI] [PubMed] [Google Scholar]
  28. Scolnick E. M., Parks W., Kawakami T., Kohne D., Okabe H., Gilden R., Hatanaka M. Primate and murine type-C viral nucleic acid association kinetics: analysis of model systems and natural tissues. J Virol. 1974 Feb;13(2):363–369. doi: 10.1128/jvi.13.2.363-369.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Sherr C. J., Todaro G. J. Primate type C virus p30 antigen in cells from humans with acute leukemia. Science. 1975 Mar 7;187(4179):855–857. doi: 10.1126/science.163489. [DOI] [PubMed] [Google Scholar]
  30. Sherr C. J., Todaro G. J. Type C viral antigens in man. I. Antigens related to endogenous primate virus in human tumors. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4703–4707. doi: 10.1073/pnas.71.12.4703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Stephension J. R., Reynolds R. K., Tronick S. R., Aaronson S. A. Distribution of three classes of endogenous type-C RNA viruses among inbred strains of mice. Virology. 1975 Oct;67(2):404–414. doi: 10.1016/0042-6822(75)90442-0. [DOI] [PubMed] [Google Scholar]
  32. Stephenson J. R., Aaronson S. A. Expression of endogenous RNA C-type virus group-specific antigens in mammalian cells. J Virol. 1973 Sep;12(3):564–569. doi: 10.1128/jvi.12.3.564-569.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Stephenson J. R., Tronick S. R., Reynolds R. K., Aaronson S. A. Isolation and characterization of C-type viral gene products of virus-negative mouse cells. J Exp Med. 1974 Feb 1;139(2):427–438. doi: 10.1084/jem.139.2.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Strand M., August J. T. Structural proteins of mammalian oncogenic RNA viruses: multiple antigenic determinants of the major internal protein and envelope glycoprotein. J Virol. 1974 Jan;13(1):171–180. doi: 10.1128/jvi.13.1.171-180.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Strickland J. E., Fowler A. K., Kind P. P., Hellman A., Kalter S. S., Heberling R. L., Helmke R. J. Group specific antigen and RNA-directed DNA polymerase activity in normal baboon placenta. Proc Soc Exp Biol Med. 1973 Oct 1;144(1):256–258. doi: 10.3181/00379727-144-37568. [DOI] [PubMed] [Google Scholar]
  36. Teich N. M., Weiss R. A., Salahuddin S. Z., Gallagher R. E., Gillespie D. H., Gallo R. C. Infective transmission and characterisation of a C-type virus released by cultured human myeloid leukaemia cells. Nature. 1975 Aug 14;256(5518):551–555. doi: 10.1038/256551a0. [DOI] [PubMed] [Google Scholar]
  37. Theilen G. H., Gould D., Fowler M., Dungworth D. L. C-type virus in tumor tissue of a woolly monkey (Lagothrix spp.) with fibrosarcoma. J Natl Cancer Inst. 1971 Oct;47(4):881–889. [PubMed] [Google Scholar]
  38. Todaro G. J., Gallo R. C. Immunological relationship of DNA polymerase from human acute leukaemia cells and primate and mouse leukaemia virus reverse transcriptase. Nature. 1973 Jul 27;244(5413):206–209. doi: 10.1038/244206a0. [DOI] [PubMed] [Google Scholar]
  39. Wong-Staal F., Gallo R. C., Gillespie D. Genetic relationship of a primate RNA tumour virus genome to genes in normal mice. Nature. 1975 Aug 21;256(5519):670–672. doi: 10.1038/256670a0. [DOI] [PubMed] [Google Scholar]

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