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. 1976 May;73(5):1761–1764. doi: 10.1073/pnas.73.5.1761

Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops.

P S Roheim, S W Brusilow
PMCID: PMC430381  PMID: 1064048

Abstract

To evaluate a possible role for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] and adenosine 3':5'-cyclic monophosphate in the secretion of endolymph, we studied the effect of an intra-scala media injection of purified cholera toxin (an adenylate cyclase stimulant) on cochlear endolymph volume, endolymphatic potential, and endolymphatic Na and K concentrations.

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Selected References

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