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(A) and (B) Growth curves of tumors established from HT-29 parental (HT-29PAR) (A) and HT-29 sunitinib resistant (HT-29SUN) (B) tumor cells after tumor cell injection (5×106 cells; n = 6). Mice received treatment with vehicle or sunitinib malate (40 mg/kg/day). (C) and (D) Tumor weights at the end of the experiment of HT-29PAR (C) and HT-29SUN (D) tumors. Results are shown as mean ± SEM (n = 6); ***, P < 0.001, NS= not significant.
