Abstract
The yeast, Saccharomyces cerevisiae, contains four types of histones resembling histones H3, H2b, H2a, and H4 of animal cells. These proteins are synthesized primarily, if not exclusively, in the S-phase of the cell cycle. This result is discussed with reference to the insensitivity of ongoing DNA replication in yeast to inhibitors of protein synthesis.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adamson E. D., Woodland H. R. Histone synthesis in early amphibian development: histone and DNA syntheses are not co-ordinated. J Mol Biol. 1974 Sep 15;88(2):263–285. doi: 10.1016/0022-2836(74)90481-1. [DOI] [PubMed] [Google Scholar]
- Borun T. W., Scharff M. D., Robbins E. Rapidly labeled, polyribosome-associated RNA having the properties of histone messenger. Proc Natl Acad Sci U S A. 1967 Nov;58(5):1977–1983. doi: 10.1073/pnas.58.5.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradbury E. M., Inglis R. J., Matthews H. R., Sarner N. Phosphorylation of very-lysine-rich histone in Physarum polycephalum. Correlation with chromosome condensation. Eur J Biochem. 1973 Feb 15;33(1):131–139. doi: 10.1111/j.1432-1033.1973.tb02664.x. [DOI] [PubMed] [Google Scholar]
- Franco L., Johns E. W., Navlet J. M. Histones from baker's yeast. Isolation and fractionation. Eur J Biochem. 1974 Jun 1;45(1):83–89. doi: 10.1111/j.1432-1033.1974.tb03532.x. [DOI] [PubMed] [Google Scholar]
- Golombek J., Wintersberger E. Glucose uptake in the cell cycle of Saccharomyces cerevisiae. Exp Cell Res. 1974 May;86(1):199–202. doi: 10.1016/0014-4827(74)90673-9. [DOI] [PubMed] [Google Scholar]
- Golombek J., Wolf W., Wintersberger E. DNA synthesis and DNA-polymerase activity in synchronized yeast cells. Mol Gen Genet. 1974;132(2):137–145. doi: 10.1007/BF00272179. [DOI] [PubMed] [Google Scholar]
- Gorovsky M. A., Keevert J. B. Absence of histone F1 in a mitotically dividing, genetically inactive nucleus. Proc Natl Acad Sci U S A. 1975 Jul;72(7):2672–2676. doi: 10.1073/pnas.72.7.2672. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hereford L. M., Hartwell L. H. Role of protein synthesis in the replication of yeast DNA. Nat New Biol. 1973 Aug 1;244(135):129–131. doi: 10.1038/newbio244129a0. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Lark K. G. Initiation and control of DNA synthesis. Annu Rev Biochem. 1969;38:569–604. doi: 10.1146/annurev.bi.38.070169.003033. [DOI] [PubMed] [Google Scholar]
- MASTER R. W. POSSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES OF KNOWN BASE-TRIPLET SEQUENCES. Nature. 1965 Apr 3;206:93–93. doi: 10.1038/206093b0. [DOI] [PubMed] [Google Scholar]
- Newlon C. S., Petes T. D., Hereford L. M., Fangman W. L. Replication of yeast chromosomal DNA. Nature. 1974 Jan 4;247(5435):32–35. doi: 10.1038/247032a0. [DOI] [PubMed] [Google Scholar]
- Panyim S., Chalkley R. High resolution acrylamide gel electrophoresis of histones. Arch Biochem Biophys. 1969 Mar;130(1):337–346. doi: 10.1016/0003-9861(69)90042-3. [DOI] [PubMed] [Google Scholar]
- Petes T. D., Williamson D. H. Fiber autoradiography of replicating yeast DNA. Exp Cell Res. 1975 Oct 1;95(1):103–110. doi: 10.1016/0014-4827(75)90614-x. [DOI] [PubMed] [Google Scholar]
- Sadgopal A., Bonner J. The relationship between histone and DNA synthesis in HeLa cells. Biochim Biophys Acta. 1969 Aug 20;186(2):349–357. doi: 10.1016/0005-2787(69)90013-6. [DOI] [PubMed] [Google Scholar]
- Seale R. L., Simpson R. T. Effects of cycloheximide on chromatin biosynthesis. J Mol Biol. 1975 May 25;94(3):479–501. doi: 10.1016/0022-2836(75)90216-8. [DOI] [PubMed] [Google Scholar]
- Tonino G. J., Rozijn T. H. On the occurrence of histones in yeast. Biochim Biophys Acta. 1966 Aug 24;124(2):427–429. doi: 10.1016/0304-4165(66)90215-7. [DOI] [PubMed] [Google Scholar]
- Weintraub H. A possible role for histone in the synthesis of DNA. Nature. 1972 Dec 22;240(5382):449–453. doi: 10.1038/240449a0. [DOI] [PubMed] [Google Scholar]
- Weintraub H., Holtzer H. Fine control of DNA synthesis in developing chick red blood cells. J Mol Biol. 1972 Apr 28;66(1):13–35. doi: 10.1016/s0022-2836(72)80003-2. [DOI] [PubMed] [Google Scholar]
- Williamson D. H. Replication of the nuclear genome in yeast does not require concomitant protein synthesis. Biochem Biophys Res Commun. 1973 Jun 8;52(3):731–740. doi: 10.1016/0006-291x(73)90998-4. [DOI] [PubMed] [Google Scholar]
- Wintersberger U., Smith P., Letnansky K. Yeast chromatin. Preparation from isolated nuclei, histone composition and transcription capacity. Eur J Biochem. 1973 Feb 15;33(1):123–130. doi: 10.1111/j.1432-1033.1973.tb02663.x. [DOI] [PubMed] [Google Scholar]