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. 1976 Jun;73(6):2077–2081. doi: 10.1073/pnas.73.6.2077

Heredity of the GIX thymocyte antigen associated with murine leukemia virus: segregation data simulating genetic linkage.

E Stockert, E A Boyse, H Sato, K Itakura
PMCID: PMC430452  PMID: 180539

Abstract

The GIX antigen is a feature of the gp70 envelope glycoprotein of murine luekemia virus (MuLV). This GIX-gp70 molecule is found on the thymocytes of some (GIX+) strains of mice, where its expression is controlled by two mendelian genes, Gv-1 and Gv-2. Previous recombination data involving the prototype GIX+ strain 129 indicated that the H-2 (chromosome 17) and Gv-1 loci are linked, at a distance of 36 units from one another. New data indicate that the association of H-2 and GIX phenotypes is an example of quasi-linkage, evidently dependent in this instance on heterozygosity at a locus or loci in the vicinity of H-2. Other previous recombination data, involving the GIX+ strain AKR, had indicated that the Gpd-1 (chromosome 4) and Gv-1 loci are linked at a distance of 19 units from one another. New data from other crosses show that this association of Gpd-1 (glucose-6-phosphate dehydrogenase 1) and GIX phenotypes also constitutes quasi-linkage, evidently due to heterozygosity at the Fv-1 locus. An important theoretical consequence of quasi-linkage in general is that it should enhance the heritability of particular constellations of unlinked genes, and so influence population structure. Our new data are discussed from the viewpoint that MuLV genomes are apparently concerned in quasi-linkage, and therefore by the same arguments may influence the genetic structure of populations. This in turn may strengthen the view that integrated MuLV genomes are not simply intruded into a self-sufficient cellular genome, but are themselves elements of the cellular genome with primary functions, perhaps in reproduction or embryogenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett D., Boyse E. A. Sex ratio in progeny of mice inseminated with sperm treated with H-Y antiserum. Nature. 1973 Nov 30;246(5431):308–309. doi: 10.1038/246308a0. [DOI] [PubMed] [Google Scholar]
  2. Boyse E. A., Old L. J., Stockert E. An approach to the mapping of antigens on the cell surface. Proc Natl Acad Sci U S A. 1968 Jul;60(3):886–893. doi: 10.1073/pnas.60.3.886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Freedman H. A., Lilly F. Properties of cell lines derived from tumors induced by Friend virus in BALB/c and BALB/c-H-2b mice. J Exp Med. 1975 Jul 1;142(1):212–223. doi: 10.1084/jem.142.1.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Geering G., Old L. J., Boyse E. A. Antigens of leukemias induced by naturally occurring murine leukemia virus: their relation to the antigens of gross virus and other murine leukemia viruses. J Exp Med. 1966 Oct 1;124(4):753–772. doi: 10.1084/jem.124.4.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ikeda H., Rowe W. P., Boyse E. A., Stockert E., Sato H., Jacobs S. Relationship of infectious murine leukemia virus and virus-related antigens in genetic crosses between AKR and the Fv-1 compatible strain C57L. J Exp Med. 1976 Jan 1;143(1):32–46. doi: 10.1084/jem.143.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ikeda H., Stockert E., Rowe W. P., Boyse E. A., Lilly F., Sato H., Jacobs S., Old L. J. Relation of chromosome 4 (linkage group 8) to murine leukemia virus-associated antigens of AKR mice. J Exp Med. 1973 Apr 1;137(4):1103–1107. doi: 10.1084/jem.137.4.1103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. LILLY F., BOYSE E. A., OLD L. J. GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS. Lancet. 1964 Dec 5;2(7371):1207–1209. doi: 10.1016/s0140-6736(64)91043-8. [DOI] [PubMed] [Google Scholar]
  8. Lerner R. A., Wilson C. B., Villano B. C., McConahey P. J., Dixon F. J. Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycorprotein, gp70. J Exp Med. 1976 Jan 1;143(1):151–166. doi: 10.1084/jem.143.1.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MICHIE D. 'Affinity'. Proc R Soc Lond B Biol Sci. 1955 Sep 27;144(915):241–259. doi: 10.1098/rspb.1955.0055. [DOI] [PubMed] [Google Scholar]
  10. Obata Y., Ikeda H., Stockert E., Boyse E. A. Relation of GIX antigen of thymocytes to envelope glycoprotein of murine leukemia virus. J Exp Med. 1975 Jan 1;141(1):188–197. doi: 10.1084/jem.141.1.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rowe W. P., Sato H. Genetic mapping of the Fv-1 lcous of the mouse. Science. 1973 May 11;180(4086):640–641. doi: 10.1126/science.180.4086.640. [DOI] [PubMed] [Google Scholar]
  12. Rowe W. P. Studies of genetic transmission of murine leukemia virus by AKR mice. I. Crosses with Fv-1 n strains of mice. J Exp Med. 1972 Nov 1;136(5):1272–1285. doi: 10.1084/jem.136.5.1272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ruddle F. H., Shows T. B., Roderick T. H. Autosomal control of an electrophoretic variant of glucose-6-phosphate dehydrogenase in the mouse (Mus musculus). Genetics. 1968 Apr;58(4):599–606. doi: 10.1093/genetics/58.4.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sato H., Boyse E. A., Aoki T., Iritani C., Old L. J. Leukemia-associated transplantation antigens related to murine leukemia virus. The X.1 system: immune response controlled by a locus linked to H-2. J Exp Med. 1973 Sep 1;138(3):593–606. doi: 10.1084/jem.138.3.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stockert E., Boyse E. A., Obata Y., Ikeda H., Sarkar N. H., Hoffman H. A. New mutant and congenic mouse stocks expressing the murine leukemia virus-associated thymocyte surface antigen GIX. J Exp Med. 1975 Aug 1;142(2):512–517. doi: 10.1084/jem.142.2.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Stockert E., Old L. J., Boyse E. A. The G-IX system. A cell surface allo-antigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome. J Exp Med. 1971 Jun 1;133(6):1334–1355. doi: 10.1084/jem.133.6.1334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stockert E., Sato H., Itakura K., Boyse E. A., Old L. J., Hutton J. J. Location of the second gene required for expression of the leukemia-associated mouse antigens G IX . Science. 1972 Nov 24;178(4063):862–863. doi: 10.1126/science.178.4063.862. [DOI] [PubMed] [Google Scholar]
  18. Strand M., Lilly F., August J. T. Host control of endogenous murine leukemia virus gene expression: concentrations of viral proteins in high and low leukemia mouse strains. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3682–3686. doi: 10.1073/pnas.71.9.3682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tung J. S., Vitetta E. S., Fleissner E., Boyse E. A. Biochemical evidence linking the GIX thymocyte surface antigen to the gp69/71 envelope glycoprotein of murine leukemia virus. J Exp Med. 1975 Jan 1;141(1):198–205. doi: 10.1084/jem.141.1.198. [DOI] [PMC free article] [PubMed] [Google Scholar]

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