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. 1976 Jul;73(7):2501–2504. doi: 10.1073/pnas.73.7.2501

Interactions between nutritional factors and drug biotransformations in man.

A P Alvares, K E Anderson, A H Conney, A Kappas
PMCID: PMC430624  PMID: 1065903

Abstract

This study was undertaken to examine the influence of nutritional factors on the activity of the mixed function oxidase system in man, which is cytochrome P-450 dependent. Three normal volunteers were fed a low carbohydrate-high protein diet for 2 weeks, followed by a high carbohydrate-low protein diet for the follwoing 2 weeks. At the end of each test diet period, the plasma elimination rates of antipyrine and theophylline were determined. The mean plasma half-life for antipyrine was 17.5 hr on the high carbohydrate-low protein diet and 9.2 hr on the low carbohydrate-high protein diet. The mean plasma half-life for theophylline was 8.9 hr on the high carbohydrate-low protein diet and 5.9 hr on the low carbohydrate-high protein diet. These data demonstrate marked influences of dietary carbohydrate and/or protein ingestion on oxidative biotransformation of drugs in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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